IDEAS home Printed from https://ideas.repec.org/a/ajp/edwast/v9y2025i8p744-751id9432.html
   My bibliography  Save this article

Transformation of SCLC into NSCLC-squamous type with invasive fungal co-infection

Author

Listed:
  • Rizki Diah Anggraeni
  • Ungky Agus Setyawan
  • Yani Jane R. S ugiri
  • Dini Rachma Erawati
  • Hendy Setyo Yudhanto

Abstract

Small Cell Lung Cancer (SCLC) is a neuroendocrine tumor with and poor prognosis. Transformation commonly occurs from NSCLC to SCLC, that caused by chemotherapy, immunotherapy, and targeted therapy resistance. This case shows a 5% rare case transformation from SCLC to NSCLC. A 69-year-old man had hemoptysis, dyspnea, and chest pain for a month. In 2017, the history of SCLC received 6 series of cisplatin-etoposide chemotherapy. CT-Scan Thorax RECIST was stable disease, and the rest of the treatment was. In April 2022, RECIST showed that the mass increased. KOH sputum obtained hyphae and conidia. Forceps biopsy found Aspergillus. Re-biopsy was squamous cell carcinoma. SCLC transformation is characterized by TP53 and RB1 gene mutations. Interferon-ỿ (INFỿ) production impairment due to IL12RB1 mutation caused macrophages to eliminate intracellular fungi. Fungal interaction (integrin-β1) on alveolar epithelial cells increases EGFR activation, cell damage, and the development of fungal invasion. Patient was given fluconazole and carboplatin-paclitaxel chemotherapy 6 series, then maintenance paclitaxel, currently stable.

Suggested Citation

  • Rizki Diah Anggraeni & Ungky Agus Setyawan & Yani Jane R. S ugiri & Dini Rachma Erawati & Hendy Setyo Yudhanto, 2025. "Transformation of SCLC into NSCLC-squamous type with invasive fungal co-infection," Edelweiss Applied Science and Technology, Learning Gate, vol. 9(8), pages 744-751.
    • Handle: RePEc:ajp:edwast:v:9:y:2025:i:8:p:744-751:id:9432
    as

    Download full text from publisher

    File URL: https://learning-gate.com/index.php/2576-8484/article/view/9432/3096
    Download Restriction: no
    ---><---

    More about this item

    Keywords

    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ajp:edwast:v:9:y:2025:i:8:p:744-751:id:9432. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Melissa Fernandes (email available below). General contact details of provider: https://learning-gate.com/index.php/2576-8484/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.