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Modulation Of Colorectal Cancer By The Probiotic Organism Lactobacillus Reuteri

Author

Listed:
  • Blasingame, Camara A.
  • Billups, Leonard H.
  • Graham, Thomas
  • Henry, JaNell
  • Carter, Brianna
  • Threadgill, David W.
  • Alexander, A. Deloris

Abstract

Probiotics are beneficial to gastrointestinal health and have anti-inflammatory properties. An experiment was conducted to determine if L. reuteri could protect mice from azoxymethaneinduced colorectal cancer (AOM-CRC). A/J mice were randomly assigned to controls, pretreatment, or post-treatment groups. The mice in the groups were injected with 10mg/kg body weight of AOM and treated with L. reuteri; given only AOM; given only L. reuteri; or given neither AOM nor L. reuteri. At the end of a 26-week latency period, the mice were euthanized, dissected, and colons examined for tumors. L. reuteri did not protect animals against tumor formation. However, L. reuteri treatment had a significant effect on tumor number when the mice were segregated by gender (p = 0.014). There was no significant effect of regimen on tumor number (p = 0.667) or tumor size (p = 0.197). Ultimately, L. reuteri exhibited probiotic properties as a potential prophylactic treatment for colitis.

Suggested Citation

  • Blasingame, Camara A. & Billups, Leonard H. & Graham, Thomas & Henry, JaNell & Carter, Brianna & Threadgill, David W. & Alexander, A. Deloris, 2016. "Modulation Of Colorectal Cancer By The Probiotic Organism Lactobacillus Reuteri," Professional Agricultural Workers Journal (PAWJ), Professional Agricultural Workers Conference, vol. 3(2), pages 1-16.
    • Handle: RePEc:ags:pawjal:236898
    DOI: 10.22004/ag.econ.236898
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    Health Economics and Policy;

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