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New Insights of Neuromedin B and its Receptor NMBR Involvement in Immunity

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  • LI, Chunyu
  • MA, Yijie
  • TIAN, Shimao
  • WAN, Qianhui
  • TANG, Mengyao
  • NING, Hongya
  • MA, Shujie
  • YANG, Guihong

Abstract

Neuromedin B (NMB) is a member of mammalian bombesin-like peptide family and almost all its potent biological actions take place exclusively through its receptor NMBR, which has been identified as a G-protein couple receptor with seven trans-membrane regions. NMB and NMBR represent an interesting signaling axis over which NMB/NMBR perform multiple biological activities, in particularly, they have been highlighted in the regulation of the immunology system. This review aims to provide a brief overview of the recent advancements in our understanding regarding the potential immunological functions of NMB and NMBR in cell proliferation, tumorigenesis, angiogenesis, neurogenic inflammation, anti-influenza A virus (IAV) infections, and briefly discusses the potential importance of these observations. All these implicated that targeting NMBR or developing analogues of NMB may represent a useful strategy for development of new anti-IAV agents.

Suggested Citation

  • LI, Chunyu & MA, Yijie & TIAN, Shimao & WAN, Qianhui & TANG, Mengyao & NING, Hongya & MA, Shujie & YANG, Guihong, 2021. "New Insights of Neuromedin B and its Receptor NMBR Involvement in Immunity," Asian Agricultural Research, USA-China Science and Culture Media Corporation, vol. 13(06), June.
    • Handle: RePEc:ags:asagre:316957
    DOI: 10.22004/ag.econ.316957
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