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Synthesis and Antibacterial Activity of Ursolic Acid Derivatives

Author

Listed:
  • Xiaoyuan Song
  • Junfang Li
  • Yimin Wang
  • Ganjun Yuan
  • Shan Lai
  • Houqin Yi
  • Pingyi Li

Abstract

To obtained natural products with remarkable antibacterial activities, three 3-amino substituted (UA) derivatives 2, 3 and 4 were designed and synthesized, and their antibacterial activity were assayed using broth microdilution method. Compared to UA, there three derivatives present higher antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) with the minimum inhibitory concentrations of 16 to 32 μg/mL. Furthermore, their cytotoxicities to human hepatoma cell (BEL-7402) were evaluated using MTT method, and the results indicated that their derivatives had no toxicity (IC50 value was larger than 10 μM), while UA presented a certain cytotoxicity.

Suggested Citation

  • Xiaoyuan Song & Junfang Li & Yimin Wang & Ganjun Yuan & Shan Lai & Houqin Yi & Pingyi Li, 2019. "Synthesis and Antibacterial Activity of Ursolic Acid Derivatives," International Journal of Sciences, Office ijSciences, vol. 8(09), pages 20-23, September.
    • Handle: RePEc:adm:journl:v:8:y:2019:i:9:p:20-23
    DOI: 10.18483/ijSci.2169
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