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Changes of Learning and Memory Ability in fos-GFP Transgenic Mice

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  • Chen W
  • Cao HaiS
  • Sun XiaoM

Abstract

Objective To study the changes of learning and memory ability in fos-GFP transgenic mice. Methods The mice in the fos-GFP group and the control were tested by using overhead cross maze,open field,and Morris Water Maze[1]. The spontaneous activity,anxiety state,the ability of learning and memory were tested as well. Results The differences between fos-GFP mice and the control were not significant in terms of distance of motion within the field,velocity,duration of stay at the marginal zone,and duration of open arm in the maze(p>0.05).The difference between the mice in the two groups was not significant with regard to latency of finding the flat at each time point(p>0.05),and the percentage of duration in target quadrant in Morris Water Maze(p>0.05),and similar freezing time in contextual fear conditioning test(p>0.05).The fos-GFP mice showed higher freezing level than normal controls in no-exposed fear conditioning(t=9.48,P

Suggested Citation

  • Chen W & Cao HaiS & Sun XiaoM, 2019. "Changes of Learning and Memory Ability in fos-GFP Transgenic Mice," International Journal of Sciences, Office ijSciences, vol. 8(02), pages 39-43, February.
    • Handle: RePEc:adm:journl:v:8:y:2019:i:2:p:39-43
    DOI: 10.18483/ijSci.1981
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