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Regulation of Feeding and Mechanisms of Intracerebroventricular Injection of Nesfatin-1 in Obese Rats

Author

Listed:
  • Xue Ruimei
  • Wang Mi
  • Leng Hui
  • Sun Xiangrong
  • Xu Luo

Abstract

Objective: Aim to discuss the effects of intracerebroventricular injection of nesfatin-1 on the feeding of normal rats and obese rats to clarify the mechanism of feeding regulation. Methods: Using the BioDAQ feeding monitoring system to monitor 24h food intake, bout size, meal size, bout frequency, meal frequency, meal interval and meal duration of rats. Results: Intracerebroventricular injection of nesfatin-1 reduced the amount of 24h food intake in normal rats, food intake at fifth hour significantly reduced; After intracerebroventricular injection of nesfatin-1 in normal rats, meal size, meal duration and the percentage of time spent eating significantly reduced, meal interval and meal frequency did not change significantly, satiety ratio significantly increased; Intracerebroventricular injection of nesfatin-1 reduced the amount of 20h food intake in obese rats, food intake at third hour significantly reduced; Intracerebroventricular injection of nesfatin-1 significantly reduced bout frequency, meal frequency and eating rate in obese rats, with a significant increase in meal interval and satiety ratio. Conclusion: Nesfatin-1 can inhibit the feeding of normal rats and obese rats. The normal rats showed increased satiation, the obese rats showed increased satiety, and the nesfatin-1 can regulate the feeding of normal rats and obese rats via different pathway.

Suggested Citation

  • Xue Ruimei & Wang Mi & Leng Hui & Sun Xiangrong & Xu Luo, 2018. "Regulation of Feeding and Mechanisms of Intracerebroventricular Injection of Nesfatin-1 in Obese Rats," International Journal of Sciences, Office ijSciences, vol. 7(04), pages 64-70, April.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:4:p:64-70
    DOI: 10.18483/ijSci.1631
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    Keywords

    Food intake; Nesfatin-1; Obesity;
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