IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v7y2018i4p64-70.html
   My bibliography  Save this article

Regulation of Feeding and Mechanisms of Intracerebroventricular Injection of Nesfatin-1 in Obese Rats

Author

Listed:
  • Xue Ruimei
  • Wang Mi
  • Leng Hui
  • Sun Xiangrong
  • Xu Luo

Abstract

Objective: Aim to discuss the effects of intracerebroventricular injection of nesfatin-1 on the feeding of normal rats and obese rats to clarify the mechanism of feeding regulation. Methods: Using the BioDAQ feeding monitoring system to monitor 24h food intake, bout size, meal size, bout frequency, meal frequency, meal interval and meal duration of rats. Results: Intracerebroventricular injection of nesfatin-1 reduced the amount of 24h food intake in normal rats, food intake at fifth hour significantly reduced; After intracerebroventricular injection of nesfatin-1 in normal rats, meal size, meal duration and the percentage of time spent eating significantly reduced, meal interval and meal frequency did not change significantly, satiety ratio significantly increased; Intracerebroventricular injection of nesfatin-1 reduced the amount of 20h food intake in obese rats, food intake at third hour significantly reduced; Intracerebroventricular injection of nesfatin-1 significantly reduced bout frequency, meal frequency and eating rate in obese rats, with a significant increase in meal interval and satiety ratio. Conclusion: Nesfatin-1 can inhibit the feeding of normal rats and obese rats. The normal rats showed increased satiation, the obese rats showed increased satiety, and the nesfatin-1 can regulate the feeding of normal rats and obese rats via different pathway.

Suggested Citation

  • Xue Ruimei & Wang Mi & Leng Hui & Sun Xiangrong & Xu Luo, 2018. "Regulation of Feeding and Mechanisms of Intracerebroventricular Injection of Nesfatin-1 in Obese Rats," International Journal of Sciences, Office ijSciences, vol. 7(04), pages 64-70, April.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:4:p:64-70
    DOI: 10.18483/ijSci.1631
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/1631
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V72018041631.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.1631?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Keywords

    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:7:y:2018:i:4:p:64-70. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.