IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v7y2018i4p56-63.html
   My bibliography  Save this article

The Effect of Oxytocin on Food Intake in the Nucleus Accumbens Core

Author

Listed:
  • Ying Zhao
  • Wang Qian
  • Wang Cheng
  • Xu Luo

Abstract

Objective: In this experiment, we mainly investigated whether oxytocin (OT) acts on the Nucleus Accumbens Core (NAc) to regulate the feeding behavior of rats. Methods: Immunohistochemical experiment was used to observe the expression of OT receptor in NAc; To observe the effect of direct injection of OT in NAc on hunger- and palatability-driven food intake; c-Fos expression can be used as a marker of neuronal activation. After the NAc injection ofOT, the expression of c-fos in the hypothalamus was observed. Results: Studies found that the NAc injection of OT significantly reduced fasting-induced food intake and reduced intake of maltose and dextrin in non-fasted rats. Administration of the OTR antagonist L-368899 within NAc completely blocked these effects induced by OT. The results showed that intra-NAc injection of OT significantly activated NAc, as well as the other two brain regions associated with feeding: hypothalamic paraventricular nucleus and supraoptic nucleus. Conclusion: Injection of OT within NAc significantly attenuated starvation and reward-induced feeding behavior.

Suggested Citation

  • Ying Zhao & Wang Qian & Wang Cheng & Xu Luo, 2018. "The Effect of Oxytocin on Food Intake in the Nucleus Accumbens Core," International Journal of Sciences, Office ijSciences, vol. 7(04), pages 56-63, April.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:4:p:56-63
    DOI: 10.18483/ijSci.1630
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/1630
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V72018041630.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.1630?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:7:y:2018:i:4:p:56-63. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.