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Effects of Ferric Ammonium Citrate (FAC) on Rab Family in SH-SY5Y Dopaminergic Cells

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  • Zhenlei Zhufu

Abstract

To examine the effects of ferric ammonium citrate (FAC) on Rab family in SH-SY5Y dopaminergic cells.Western blot was used to investigate Rab7,Rab11,Rab27a and Rab35 protein levels in SH-SY5Y dopaminegic cells with FAC for 4h and 12h.When SH-SY5Y cells were treated with 100 μmol/L or 1 mmol/L FAC for 4h and 12 h, Rab7, Rab11 and Rab27a protein levels was not significantly different from those of the control group.However, Rab35 protein was significantly up-regulated in SH-SY5Y cells with 1 mmol/L FACtreatment.Iron overloadupregulates Rab35 protein expressionin SH-SY5Y dopaminergic cells.

Suggested Citation

  • Zhenlei Zhufu, 2018. "Effects of Ferric Ammonium Citrate (FAC) on Rab Family in SH-SY5Y Dopaminergic Cells," International Journal of Sciences, Office ijSciences, vol. 7(10), pages 30-33, October.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:10:p:30-33
    DOI: 10.18483/ijSci.1810
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    Keywords

    Iron; SH-SY5Y Cells; Rab;
    All these keywords.

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