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Cationic Quaternized Chitosan Nanoparticles for C-phycocyanin Delivery to Hela Cells

Author

Listed:
  • Peng Yang
  • Bing Li
  • Cong-Yi Lv
  • Qi-Feng Yin
  • Yu-Juan Wang

Abstract

In this study we synthesize C-PC/QAC nanoparticles using cationic quaternary ammonium chitosan (QAC) as substrate material loaded C-phycocyanin (C-PC) by ionic-gelation method. The prepared NPs was about 120nm size with spherical morphology, the entrapment efficient was 62%, and the drug-loading amount was 20%. The NPs exhibited a pH sensitive realease of C-PC in vitro. The drug-NPs were proved to be hemocompatible and safe. In conclusion, QAC increased bioavailability and anticancer property of C-PC.

Suggested Citation

  • Peng Yang & Bing Li & Cong-Yi Lv & Qi-Feng Yin & Yu-Juan Wang, 2015. "Cationic Quaternized Chitosan Nanoparticles for C-phycocyanin Delivery to Hela Cells," International Journal of Sciences, Office ijSciences, vol. 4(09), pages 17-23, September.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:9:p:17-23
    DOI: 10.18483/ijSci.834
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