IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v4y2015i1p8-17.html
   My bibliography  Save this article

Whole Genome Microarray Analysis In Invasive Ductal Breast Cancer Revealed The Most Significant Changes Affect Chromosomes 1, 8, 17 And 20

Author

Listed:
  • Ivanka Dimova
  • Radka Tafradzhiska-Hadzhiolova
  • Svilen Maslyankov
  • Desislava Nesheva
  • Draga Toncheva

Abstract

Despite of the large number of molecular studies in breast cancer, the data are still insufficient for understanding its molecular pathogenesis. The dramatic development of genetics in recent years has made it possible to gain insight into the molecular mechanisms of tumorigenesis. The aims of the study was to determine the type, frequency and fine mapping of unbalanced genomic alterations in ductal carcinoma of the breast. For this study we have used tumor samples of invasive ductal breast cancer to be analysed by comparative genomic hybridization on DNA microarrays. Two approaches were applied in the analysis of significant unbalanced genomic changes: a) identification of clones which presented unbalanced changes (log2 T: H> +0.25 for gain and +0.5) or homozygous deletions (log2 T: H

Suggested Citation

  • Ivanka Dimova & Radka Tafradzhiska-Hadzhiolova & Svilen Maslyankov & Desislava Nesheva & Draga Toncheva, 2015. "Whole Genome Microarray Analysis In Invasive Ductal Breast Cancer Revealed The Most Significant Changes Affect Chromosomes 1, 8, 17 And 20," International Journal of Sciences, Office ijSciences, vol. 4(01), pages 8-17, January.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:1:p:8-17
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/611
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V420150105.pdf
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:4:y:2015:i:1:p:8-17. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.