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Expression and Significance of Beclin-1 and Bcl-2 in Gastric Cancer

Author

Listed:
  • Mei Lin
  • Wenmin YUAN
  • Xiaohui SUN
  • Zhiqiang QIN

Abstract

Objective To investigate the role and correlation of Beclin-1 and Bcl-2 in the occurrence and progression of gastric cancer. Methods The expression of Beclin-1 and Bcl-2 in 78 cases of gastric cancer, 30 cases of atypical hyperplasia and 20 cases of chronic non-atrophic gastritis was examined by immunohistochemical staining. Results The positive rate of Beclin-1 in gastric cancer was significantly lower than those in atypical hyperplasia and chronic non-atrophic gastritis(χ2=9.298,7.437, P 0.05). The positive rate of Bcl-2 in gastric cancer was significantly higher than those in atypical hyperplasia and chronic non-atrophic gastritis(χ2=11.013, 15.278, P 0.05). The expression of Beclin-1 and Bcl-2 was significantly correlated with differentiation, depth of invasion and TNM staging(χ2=7.014~16.248, P>0.05), but not correlated with sex, age, tumor size, tumor location and metastasis(P>0.05). The expression of Beclin-1 was negatively correlated with Bcl-2 in gastric cancer(r=-0.396, P

Suggested Citation

  • Mei Lin & Wenmin YUAN & Xiaohui SUN & Zhiqiang QIN, 2015. "Expression and Significance of Beclin-1 and Bcl-2 in Gastric Cancer," International Journal of Sciences, Office ijSciences, vol. 4(12), pages 58-61, December.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:12:p:58-61
    DOI: 10.18483/ijSci.879
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