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Age-Dependent Effects C57BL/6 Genetic Mutations under Mice Models of Parkinson’s Disease on Motor Ability

Author

Listed:
  • Lin Hou
  • Zhixiang Chen
  • Shengmin Zhao
  • Yaoyue Wei

Abstract

As literature reported, C57BL/6 A53T mutant human alpha-synuclein under the mice is one successful model related to Parkinson’s disease(PD). In previous studies, over-accumulation of alpha-synuclein which lead to lewy body, were revealed to cause impairment on motor ability in Parkinson’s disease mouse model. Nevertheless, in the open filed test and the rota-rod test, hyperactivity and motor ability improvements at 12 months old was found in our study.

Suggested Citation

  • Lin Hou & Zhixiang Chen & Shengmin Zhao & Yaoyue Wei, 2015. "Age-Dependent Effects C57BL/6 Genetic Mutations under Mice Models of Parkinson’s Disease on Motor Ability," International Journal of Sciences, Office ijSciences, vol. 4(10), pages 9-11, October.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:10:p:9-11
    DOI: 10.18483/ijSci.855
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