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Olfactory Discrimination Deficits in A53T Alpha-Synuclein Transgenic Mice at 3 Months

Author

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  • Yu Zhou
  • Zegang Ma
  • Qi Liu

Abstract

Parkinson’s disease (PD) is a kind of typical neurodegenerative diseases. Previously, clinical studies have showed that deficits in olfactory and cognitive functions precede motor-symptoms in PD. However, the mechanisms of olfactory discrimination deficits in early stage of PD is still unknown. In this study, we aimed to clarify the characteristics of olfactory deficits in A53T transgenic mice and test the possible mechanisms involved. By the elevated plus maze and bedding test, we showed that A53T transgenic mice at 3 months exhibit no hyperactivity behavior. Olfactory discrimination test indicated wild-type mice spent more time in old bedding than in new bedding during 5 min test (*P

Suggested Citation

  • Yu Zhou & Zegang Ma & Qi Liu, 2015. "Olfactory Discrimination Deficits in A53T Alpha-Synuclein Transgenic Mice at 3 Months," International Journal of Sciences, Office ijSciences, vol. 4(10), pages 12-15, October.
    • Handle: RePEc:adm:journl:v:4:y:2015:i:10:p:12-15
    DOI: 10.18483/ijSci.854
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