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Therapeutic Effects of Kv7 Channel Activator Retigabine against Seizures and Neurodegeneration in Kainic Acid-Induced Seizure Model

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  • Xiao-fei Zhuang

Abstract

Aims: The current study evaluates whether Kv7 channel activator retigabine (RTG) could attenuate seizures and hippocampal neurodegeneration in the kainic acid (KA) induced seizure model. Methods: The anticonvulsant activity of RTG is evaluated by electroencephalography (EEG) recordings in KA-kindled rats. Tunel assay and immunofluorescence of NeuN are used to evaluate the neuroprotective effect of RTG in the hippocampus of KA-kindled rats. Results: RTG effectively reduces epileptiform discharges induced by KA injection. Tunel assay and immunofluorescence of NeuN show that RTG exerts neuroprotection in the hippocampus of KA-kindled rats. Conclusion: Taken together, this study demonstrates that RTG effectively alleviates seizures and hippocampal neurodegeneration in the KA-induced seizure model.

Suggested Citation

  • Xiao-fei Zhuang, 2022. "Therapeutic Effects of Kv7 Channel Activator Retigabine against Seizures and Neurodegeneration in Kainic Acid-Induced Seizure Model," International Journal of Sciences, Office ijSciences, vol. 11(07), pages 9-14, July.
    • Handle: RePEc:adm:journl:v:11:y:2022:i:7:p:9-14
    DOI: 10.18483/ijSci.2598
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