IDEAS home Printed from https://ideas.repec.org/a/aad/iseicj/v5y2017i0p1266-1274.html
   My bibliography  Save this article

Stability Evaluation Of Caffeine-8-Thioglicolic Acid Amides, With Determined Antihypoxic Effects

Author

Listed:
  • Javor Mitkov

    (Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia, Bulgaria)

  • Maya Georgieva

    (Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia, Bulgaria)

  • Alexander Zlatkov

    (Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia, Bulgaria)

Abstract

This study evaluates a series of caffeine-8-thioglycolic acid amides that were synthesized in the study, for signs of possible degradation. The chemical stability of the test compounds was examined under different conditions of pH and temperature over time. A modified reversed phase-high-performance liquid chromatography method was applied to determine stability and identify possible degradation products. The study identified a new product from oxidative destruction of the test compound through controlled synthesis.

Suggested Citation

  • Javor Mitkov & Maya Georgieva & Alexander Zlatkov, 2017. "Stability Evaluation Of Caffeine-8-Thioglicolic Acid Amides, With Determined Antihypoxic Effects," CBU International Conference Proceedings, ISE Research Institute, vol. 5(0), pages 1266-1274, September.
    • Handle: RePEc:aad:iseicj:v:5:y:2017:i:0:p:1266-1274
    DOI: 10.12955/cbup.v5.1107
    as

    Download full text from publisher

    File URL: https://ojs.journals.cz/index.php/CBUIC/article/view/1107/1653
    Download Restriction: no
    File URL: https://libkey.io/10.12955/cbup.v5.1107?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:aad:iseicj:v:5:y:2017:i:0:p:1266-1274. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Petr Hájek (email available below). General contact details of provider: https://ojs.journals.cz/index.php/CBUIC .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.