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Evaluation Of A Group Of Pyrrole Derivatives As Tuberculostatic Agents

Author

Listed:
  • Maya Georgieva

    (Medical University, Faculty of Pharmacy, Sofia, Bulgaria)

  • Diana Tzankova

    (Medical University, Faculty of Pharmacy, Sofia, Bulgaria)

  • Stanislava Vladimirova

    (University of Chemical Technology and Metallurgy, Sofia, Bulgaria)

  • Atanas Bijev

    (University of Chemical Technology and Metallurgy, Sofia, Bulgaria)

Abstract

: This research aims to contribute to the global search for more effective tuberculostatics that has been triggered by recent outbreaks of tuberculosis. A group of pyrrole-containing derivatives are designed and theoretically elucidated. The identification of the pharmacophore group using the PharmaGist webserver is attempted. Also, the corresponding drug-like properties of the tested compounds are evaluated, together with their possible toxicity risks. The pharmacokinetic behavior of the structures is predicted, based on the Lipinski’s Rule of Five. The effects of some structural parameters are tested. In addition, in vitro evaluations of the anti-tubercular activity against Mycobacterium tuberculosis H37Rv are performed, with compound GA-9 registering the highest activity.

Suggested Citation

  • Maya Georgieva & Diana Tzankova & Stanislava Vladimirova & Atanas Bijev, 2017. "Evaluation Of A Group Of Pyrrole Derivatives As Tuberculostatic Agents," CBU International Conference Proceedings, ISE Research Institute, vol. 5(0), pages 1083-1091, September.
    • Handle: RePEc:aad:iseicj:v:5:y:2017:i:0:p:1083-1091
    DOI: 10.12955/cbup.v5.1075
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