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Association of mirna-29a expression and HSV-1 infection in type 2 diabetes mellitus

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  • Nael shakir Mohamed

  • Dunya Fareed Salloom

Abstract

To investigate the association between miR-29a expression, HSV-1, TNF-α infection, and type 2 diabetes mellitus (T2DM). A case-control study was conducted on 89 T2DM patients and 88 healthy individuals, analyzing miR-29a gene expression using RT-qPCR and assessing anti-HSV-1 IgG antibody and TNFα serum level via ELISA technique. They revealed a significant upregulation of miR-29a in T2DM patients (P < 0.0001), indicating a link between inflammation and diabetes progression, and significant higher levels of TNF-α in T2DM patients (P < 0.0001), indicated the pathologic role in metabolic dysfunction and a positive correlation with insulin resistance. However, HSV-1 IgG seropositivity showed no significant association with T2DM (P > 0.05), suggesting that prior HSV-1 exposure may not be a reliable biomarker for diabetes risk. ROC analysis demonstrated high sensitivity (1.0) but low specificity (0.023), highlighting the need for improve diagnosing models. These findings underscore the considerably of miR-29a as a potential biomarker for T2DM and emphasize the role of inflammatory pathways in illness progression.

Suggested Citation

  • Nael shakir Mohamed & Dunya Fareed Salloom, 2025. "Association of mirna-29a expression and HSV-1 infection in type 2 diabetes mellitus," International Journal of Innovative Research and Scientific Studies, Innovative Research Publishing, vol. 8(6), pages 2903-2914.
    • Handle: RePEc:aac:ijirss:v:8:y:2025:i:6:p:2903-2914:id:10226
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