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Soluble FMS-like tyrosine kinase-1/Pro- angiogenic placental growth factor (sFlt- 1/PlGF) ratio as an early predictor for oxygenation impairment in preeclampsia

Author

Listed:
  • Anindya Arianditha Ardani
  • Mariza Fitriati
  • Prananda Surya Airlangga
  • Lila Tri Harjana
  • Manggala Pasca Wardhana

Abstract

Preeclampsia is a major cause of maternal mortality worldwide, with angiogenic imbalance playing a central role in its pathophysiology. This study aimed to investigate the relationship between the soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) ratio and oxygenation impairment in preeclamptic patients. A cross-sectional observational study was conducted on 47 women with singleton pregnancies diagnosed with preeclampsia at a gestational age beyond 34 weeks who underwent cesarean delivery. Data were obtained from medical records, including sFlt-1 and PlGF serum levels, sFlt-1/PlGF ratio, and arterial blood gas analysis for calculating PaO₂/FiO₂ (P/F) ratios. A significant negative correlation was found between the sFlt-1/PlGF ratio and the P/F ratio (r = -0.514, p < 0.001), indicating that a higher angiogenic imbalance is associated with poorer oxygenation status. Receiver operating characteristic (ROC) curve analysis revealed a cut-off value of 138.58 for the sFlt-1/PlGF ratio, with 83.33% sensitivity and 80% specificity for predicting oxygenation impairment. These findings suggest that the sFlt-1/PlGF ratio may serve as an early biomarker for detecting oxygenation disturbances in preeclampsia, supporting timely clinical interventions.

Suggested Citation

  • Anindya Arianditha Ardani & Mariza Fitriati & Prananda Surya Airlangga & Lila Tri Harjana & Manggala Pasca Wardhana, 2025. "Soluble FMS-like tyrosine kinase-1/Pro- angiogenic placental growth factor (sFlt- 1/PlGF) ratio as an early predictor for oxygenation impairment in preeclampsia," International Journal of Innovative Research and Scientific Studies, Innovative Research Publishing, vol. 8(4), pages 1370-1375.
    • Handle: RePEc:aac:ijirss:v:8:y:2025:i:4:p:1370-1375:id:8077
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