A Few Special Cases: Scientific Creativity and Network Dynamics in the Field of Rare Diseases
AbstractWe develop a model of scientific creativity and test it in the field of rare diseases. Our model is based on the results of an in-depth case study of the Rett syndrome. Archival analysis, bibliometric techniques and expert surveys are combined with network analysis to identify the most creative scientists. First, alternative measures of generative and combinatorial creativity are compared. Then, we generalize our results and present a stochastic model of socio-semantic network evolution. The model predictions are tested with multiple networks of rare disease specialties. We find that new scientific collaborations among experts in a field enhance combinatorial creativity. Instead, high entry rates of novices are negatively related to generative creativity. By extending the set of useful concepts, creative scientists gain in centrality. At the same time, by increasing their centrality in the scientific community, scientists can replicate and generalize their results, thus contributing to a scientific paradigm.
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Bibliographic InfoPaper provided by Department of Computer and Management Sciences, University of Trento, Italy in its series DISA Working Papers with number 2011/03.
Length: 35 pages
Date of creation: Mar 2011
Date of revision: 24 May 2011
Postal: DISA Università degli Studi di Trento via Inama, 5 I-38122 Trento TN Italy
Find related papers by JEL classification:
- C63 - Mathematical and Quantitative Methods - - Mathematical Methods; Programming Models; Mathematical and Simulation Modeling - - - Computational Techniques
- L14 - Industrial Organization - - Market Structure, Firm Strategy, and Market Performance - - - Transactional Relationships; Contracts and Reputation
- L26 - Industrial Organization - - Firm Objectives, Organization, and Behavior - - - Entrepreneurship
- L65 - Industrial Organization - - Industry Studies: Manufacturing - - - Chemicals; Rubber; Drugs; Biotechnology
- O31 - Economic Development, Technological Change, and Growth - - Technological Change; Research and Development; Intellectual Property Rights - - - Innovation and Invention: Processes and Incentives
- O33 - Economic Development, Technological Change, and Growth - - Technological Change; Research and Development; Intellectual Property Rights - - - Technological Change: Choices and Consequences; Diffusion Processes
This paper has been announced in the following NEP Reports:
- NEP-ALL-2011-10-15 (All new papers)
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- David W. Galenson & Bruce A. Weinberg, 2001. "Creating Modern Art: The Changing Careers of Painters in France from Impressionism to Cubism," American Economic Review, American Economic Association, vol. 91(4), pages 1063-1071, September.
- David Lane & Franco Malerba & Robert Maxfield & Luigi Orsenigo, 1995.
"Choice and Action,"
95-01-004, Santa Fe Institute.
- Martin L. Weitzman, 1995.
Harvard Institute of Economic Research Working Papers
1722, Harvard - Institute of Economic Research.
- Bruckner, E, et al, 1996. "Nonlinear Stochastic Effects of Substitution--An Evolutionary Approach," Journal of Evolutionary Economics, Springer, vol. 6(1), pages 1-30, February.
- Jason Owen-Smith & Massimo Riccaboni & Fabio Pammolli & Walter W. Powell, 2002.
"A Comparison of U.S. and European University-Industry Relations in the Life Sciences,"
INFORMS, vol. 48(1), pages 24-43, January.
- Jason Owen-Smith & Massimo Riccaboni & Fabio Pammolli & Walter W. Powell, 2001. "A Comparison of U.S. And European University-Industry Relations in the Life Sciences," LEM Papers Series 2001/03, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
- Owen-Smith, Jason & Riccaboni, Massimo & Pammolli, Fabio & Powell, Walter W., 2002. "A Comparison of U.S. and European University-Industry Relations in the Life Sciences," MPRA Paper 15963, University Library of Munich, Germany.
- Chen, Chaomei & Chen, Yue & Horowitz, Mark & Hou, Haiyan & Liu, Zeyuan & Pellegrino, Donald, 2009. "Towards an explanatory and computational theory of scientific discovery," Journal of Informetrics, Elsevier, vol. 3(3), pages 191-209.
- Orsenigo, L. & Pammolli, F. & Riccaboni, Massimo, 2001. "Technological change and network dynamics: Lessons from the pharmaceutical industry," Research Policy, Elsevier, vol. 30(3), pages 485-508, March.
- Nigel Gilbert, 1997. "A Simulation of the Structure of Academic Science," Sociological Research Online, Sociological Research Online, vol. 2(2), pages 3.
- Rinia, E. J. & van Leeuwen, Th. N. & van Vuren, H. G. & van Raan, A. F. J., 1998. "Comparative analysis of a set of bibliometric indicators and central peer review criteria: Evaluation of condensed matter physics in the Netherlands," Research Policy, Elsevier, vol. 27(1), pages 95-107, May.
- Lambiotte, R. & Panzarasa, P., 2009. "Communities, knowledge creation, and information diffusion," Journal of Informetrics, Elsevier, vol. 3(3), pages 180-190.
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