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Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits

Author

Listed:
  • Laibson, David I.
  • Rietveld, Cornelius A.
  • Conley, Dalton
  • Eriksson, Nicholas
  • Esko, Tonu
  • Medland, Sarah E.
  • Vinkhuyzen, Anna A. E.
  • Yang, Jian
  • Boardman, Jason D.
  • Chabris, Christopher F.
  • Dawes, Christopher T.
  • Domingue, Benjamin W.
  • Hinds, David A.
  • Johannesson, Magnus
  • Kiefer, Amy K.
  • Magnusson, Patrik K. E.
  • Mountain, Joanna L.
  • Oskarsson, Sven
  • Rostapshova, Olga
  • Teumer, Alexander
  • Tung, Joyce Y.
  • Visscher, Peter M.
  • Benjamin, Daniel J.
  • Cesarini, David
  • Koellinger, Philipp D.

Abstract

A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each \(R^2 \approx 0.02\%)\), reached genome-wide significance \((p

Suggested Citation

  • Laibson, David I. & Rietveld, Cornelius A. & Conley, Dalton & Eriksson, Nicholas & Esko, Tonu & Medland, Sarah E. & Vinkhuyzen, Anna A. E. & Yang, Jian & Boardman, Jason D. & Chabris, Christopher F. &, 2014. "Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits," Scholarly Articles 33371478, Harvard University Department of Economics.
    • Handle: RePEc:hrv:faseco:33371478
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    Citations

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    Cited by:

    1. Sanz-de-Galdeano, Anna & Terskaya, Anastasia, 2019. "Sibling Differences in Educational Polygenic Scores: How Do Parents React?," IZA Discussion Papers 12375, Institute of Labor Economics (IZA).
    2. Pankaj C. Patel & Cornelius A. Rietveld & Ingrid Verheul, 2021. "Attention Deficit Hyperactivity Disorder (ADHD) and Earnings in Later-Life Self-Employment," Entrepreneurship Theory and Practice, , vol. 45(1), pages 43-63, January.
    3. Nicola Barban & Elisabetta De Cao & Sonia Oreffice & Climent Quintana-Domeque, 2016. "Assortative Mating on Education: A Genetic Assessment," Working Papers 2016-034, Human Capital and Economic Opportunity Working Group.
    4. Nicholas W Papageorge & Kevin Thom, 2020. "Genes, Education, and Labor Market Outcomes: Evidence from the Health and Retirement Study," Journal of the European Economic Association, European Economic Association, vol. 18(3), pages 1351-1399.
    5. Mattia Prosperi & Jiang Bian & Iain E. Buchan & James S. Koopman & Matthew Sperrin & Mo Wang, 2019. "Raiders of the lost HARK: a reproducible inference framework for big data science," Palgrave Communications, Palgrave Macmillan, vol. 5(1), pages 1-12, December.
    6. Cornelius A. Rietveld & Pankaj C. Patel, 2019. "ADHD and later-life labor market outcomes in the United States," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(7), pages 949-967, September.
    7. Barban, Nicola & De Cao, Elisabetta & Oreffice, Sonia & Quintana-Domeque, Climent, 2021. "The effect of education on spousal education: A genetic approach," Labour Economics, Elsevier, vol. 71(C).
    8. Bierut, Laura & Biroli, Pietro & Galama, Titus J. & Thom, Kevin, 2023. "Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking," Journal of Economic Psychology, Elsevier, vol. 98(C).
    9. Dixon, Padraig & Hollingworth, William & Harrison, Sean & Davies, Neil M. & Davey Smith, George, 2020. "Mendelian Randomization analysis of the causal effect of adiposity on hospital costs," Journal of Health Economics, Elsevier, vol. 70(C).
    10. Cornelius A. Rietveld & Eric A.W. Slob & A. Roy Thurik, 2021. "A decade of research on the genetics of entrepreneurship: a review and view ahead," Small Business Economics, Springer, vol. 57(3), pages 1303-1317, October.
    11. Thomas Buser & Rafael Ahlskog & Magnus Johannesson & Philipp Koellinger & Sven Oskarsson, 2021. "Using Genes to Explore the Effects of Cognitive and Non-cognitive Skills on Education and Labor Market Outcomes," Tinbergen Institute Discussion Papers 21-088/I, Tinbergen Institute, revised 29 Mar 2023.

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