IDEAS home Printed from https://ideas.repec.org/p/arx/papers/2003.04620.html
   My bibliography  Save this paper

Multilayer Network Analysis of the Drug Pipeline in the Global Pharmaceutical Industry

Author

Listed:
  • Hiromitsu Goto
  • Wataru Souma
  • Mari Jibu
  • Yuichi Ikeda

Abstract

Generally, open innovation is a lucrative research topic within industries relying on innovation, such as the pharmaceutical industry, which are also known as knowledge-intensive industries. However, the dynamics of drug pipelines within a small-medium enterprise level in the global economy remains concerning. To reveal the actual situation of pharmaceutical innovation, we investigate the feature of knowledge flows between the licensor and licensee in the drug pipeline based on a multilayer network constructed with the drug pipeline, global supply chain, and ownership data. Thus, our results demonstrate proven similarities between the knowledge flows in the drug pipeline among the supply chains, which generally agrees with the situation of pharmaceutical innovation collaborated with other industries, such as the artificial intelligence industry.

Suggested Citation

  • Hiromitsu Goto & Wataru Souma & Mari Jibu & Yuichi Ikeda, 2020. "Multilayer Network Analysis of the Drug Pipeline in the Global Pharmaceutical Industry," Papers 2003.04620, arXiv.org.
  • Handle: RePEc:arx:papers:2003.04620
    as

    Download full text from publisher

    File URL: http://arxiv.org/pdf/2003.04620
    File Function: Latest version
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Aoyama,Hideaki & Fujiwara,Yoshi & Ikeda,Yuichi & Iyetomi,Hiroshi & Souma,Wataru Preface by-Name:Yoshikawa,Hiroshi, 2010. "Econophysics and Companies," Cambridge Books, Cambridge University Press, number 9780521191494.
    2. Comanor, William S. & Scherer, F.M., 2013. "Mergers and innovation in the pharmaceutical industry," Journal of Health Economics, Elsevier, vol. 32(1), pages 106-113.
    3. Yang, Jianmei & Wang, Wenjie & Chen, Guanrong, 2009. "A two-level complex network model and its application," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(12), pages 2435-2449.
    4. Abhijit Chakraborty & Yuichi Kichikawa & Takashi Iino & Hiroshi Iyetomi & Hiroyasu Inoue & Yoshi Fujiwara & Hideaki Aoyama, 2018. "Hierarchical communities in the walnut structure of the Japanese production network," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-25, August.
    5. Bronwyn H. Hall & Nathan Rosenberg (ed.), 2010. "Handbook of the Economics of Innovation," Handbook of the Economics of Innovation, Elsevier, edition 1, volume 1, number 1.
    6. Sergey V. Buldyrev & Roni Parshani & Gerald Paul & H. Eugene Stanley & Shlomo Havlin, 2010. "Catastrophic cascade of failures in interdependent networks," Nature, Nature, vol. 464(7291), pages 1025-1028, April.
    7. Nic Fleming, 2018. "How artificial intelligence is changing drug discovery," Nature, Nature, vol. 557(7707), pages 55-57, May.
    8. Martin Rosvall & Carl T Bergstrom, 2011. "Multilevel Compression of Random Walks on Networks Reveals Hierarchical Organization in Large Integrated Systems," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-10, April.
    9. J. Donges & H. Schultz & N. Marwan & Y. Zou & J. Kurths, 2011. "Investigating the topology of interacting networks," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 84(4), pages 635-651, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Zhou, Yinzuo & Zhou, Jie, 2018. "Algorithm for multiplex network generation with shared links," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 509(C), pages 945-954.
    2. Balint, T. & Lamperti, F. & Mandel, A. & Napoletano, M. & Roventini, A. & Sapio, A., 2017. "Complexity and the Economics of Climate Change: A Survey and a Look Forward," Ecological Economics, Elsevier, vol. 138(C), pages 252-265.
    3. Billette de Villemeur, Etienne & Versaevel, Bruno, 2019. "One lab, two firms, many possibilities: On R&D outsourcing in the biopharmaceutical industry," Journal of Health Economics, Elsevier, vol. 65(C), pages 260-283.
    4. Abhijit Chakraborty & Yuichi Kichikawa & Takashi Iino & Hiroshi Iyetomi & Hiroyasu Inoue & Yoshi Fujiwara & Hideaki Aoyama, 2018. "Hierarchical communities in the walnut structure of the Japanese production network," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-25, August.
    5. Shekhtman, Louis M. & Danziger, Michael M. & Havlin, Shlomo, 2016. "Recent advances on failure and recovery in networks of networks," Chaos, Solitons & Fractals, Elsevier, vol. 90(C), pages 28-36.
    6. Daisuke Sato & Yuichi Ikeda & Shuichi Kawai & Maxmilian Schich, 2020. "The sustainability and the survivability of Kyoto’s traditional craft industry revealed from supplier-customer network," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-23, November.
    7. FUJIWARA Yoshi & INOUE Hiroyasu & YAMAGUCHI Takayuki & AOYAMA Hideaki & TANAKA Takuma & KIKUCHI Kentaro, 2021. "Money Flow Network Among Firms' Accounts in a Regional Bank of Japan," Discussion papers 21005, Research Institute of Economy, Trade and Industry (RIETI).
    8. Corrado Di Guilmi & Yoshi Fujiwara, 2020. "Does the supply network shape the firm size distribution? The Japanese case," CAMA Working Papers 2020-66, Centre for Applied Macroeconomic Analysis, Crawford School of Public Policy, The Australian National University.
    9. Youba Nait Belaid & Patrick Coudray & José Sanchez-Torres & Yi-Ping Fang & Zhiguo Zeng & Anne Barros, 2021. "Resilience Quantification of Smart Distribution Networks—A Bird’s Eye View Perspective," Energies, MDPI, vol. 14(10), pages 1-29, May.
    10. repec:hal:spmain:info:hdl:2441/1nlv566svi86iqtetenms15tc4 is not listed on IDEAS
    11. repec:hal:spmain:info:hdl:2441/5qr7f0k4sk8rbq4do5u6v70rm0 is not listed on IDEAS
    12. Ute Laermann-Nguyen & Martin Backfisch, 2021. "Innovation crisis in the pharmaceutical industry? A survey," SN Business & Economics, Springer, vol. 1(12), pages 1-37, December.
    13. Julian Maluck & Reik V Donner, 2015. "A Network of Networks Perspective on Global Trade," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-24, July.
    14. Havlin, Shlomo & Stanley, H. Eugene & Bashan, Amir & Gao, Jianxi & Kenett, Dror Y., 2015. "Percolation of interdependent network of networks," Chaos, Solitons & Fractals, Elsevier, vol. 72(C), pages 4-19.
    15. Hideaki Aoyama, 2021. "XRP Network and Proposal of Flow Index," Papers 2106.10012, arXiv.org.
    16. Abhijit Chakraborty & Yuichi Ikeda, 2020. "Bow-tie structure and community identification of global supply chain network," Papers 2003.02343, arXiv.org.
    17. Yoshi Fujiwara & Hiroyasu Inoue & Takayuki Yamaguchi & Hideaki Aoyama & Takuma Tanaka, 2020. "Money flow network among firms' accounts in a regional bank of Japan," Papers 2007.14630, arXiv.org, revised Jul 2020.
    18. Bier, Vicki & Gutfraind, Alexander, 2019. "Risk analysis beyond vulnerability and resilience – characterizing the defensibility of critical systems," European Journal of Operational Research, Elsevier, vol. 276(2), pages 626-636.
    19. Hickfang, Michael & Holder, Ulrike, 2018. "The impact of stock options on risk-taking: Founder-CEOs and innovation," Discussion Papers of the Institute for Organisational Economics 12/2018, University of Münster, Institute for Organisational Economics.
    20. Jan Fagerberg & Bengt-Åke Lundvall & Martin Srholec, 2018. "Global Value Chains, National Innovation Systems and Economic Development," The European Journal of Development Research, Palgrave Macmillan;European Association of Development Research and Training Institutes (EADI), vol. 30(3), pages 533-556, July.
    21. Kurz, Michael & Kleimeier, Stefanie, 2019. "Credit Supply: Are there negative spillovers from banks’ proprietary trading? (RM/19/005-revised-)," Research Memorandum 026, Maastricht University, Graduate School of Business and Economics (GSBE).
    22. Atal, Vidya & Bar, Talia & Gordon, Sidartha, 2016. "Project selection: Commitment and competition," Games and Economic Behavior, Elsevier, vol. 96(C), pages 30-48.

    More about this item

    NEP fields

    This paper has been announced in the following NEP Reports:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:arx:papers:2003.04620. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: arXiv administrators (email available below). General contact details of provider: http://arxiv.org/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.