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Multivariate random-effects meta-analysis

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  • Ian R. White

    (MRC Biostatistics Unit)

Abstract

Multivariate meta-analysis combines estimates of several related parameters over several studies. These parameters can, for example, refer to multiple outcomes or comparisons between more than two groups. A new Stata command, mvmeta, performs maximum likelihood, restricted maximum likelihood, or method- of-moments estimation of random-effects multivariate meta-analysis models. A utility command, mvmeta_make, facilitates the preparation of summary datasets from more detailed data. The commands are illustrated with data from the Fibrinogen Studies Collaboration, a meta-analysis of observational studies; I estimate the shape of the association between a quantitative exposure and disease events by grouping the quantitative exposure into several categories. Copyright 2009 by StataCorp LP.

Suggested Citation

  • Ian R. White, 2009. "Multivariate random-effects meta-analysis," Stata Journal, StataCorp LP, vol. 9(1), pages 40-56, March.
    • Handle: RePEc:tsj:stataj:v:9:y:2009:i:1:p:40-56
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    References listed on IDEAS

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    1. Roger M. Harbord & Julian P.T. Higgins, 2008. "Meta-regression in Stata," Stata Journal, StataCorp LP, vol. 8(4), pages 493-519, December.
    2. Vic Hasselblad, 1998. "Meta-analysis of Multitreatment Studies," Medical Decision Making, , vol. 18(1), pages 37-43, January.
    3. S. le Cessie & J. C. van Houwelingen, 1992. "Ridge Estimators in Logistic Regression," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 41(1), pages 191-201, March.
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    Cited by:

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    2. Ian R. White, 2011. "Multivariate random-effects meta-regression: Updates to mvmeta," Stata Journal, StataCorp LP, vol. 11(2), pages 255-270, June.
    3. Elena Kulinskaya & Stephan Morgenthaler & Robert G. Staudte, 2014. "Combining Statistical Evidence," International Statistical Review, International Statistical Institute, vol. 82(2), pages 214-242, August.
    4. Evangelos Kontopantelis & David Reeves, 2010. "metaan: Random-effects meta-analysis," Stata Journal, StataCorp LP, vol. 10(3), pages 395-407, September.
    5. Jeffrey L Jackson & Akira Kuriyama & Yachiyo Kuwatsuka & Sarah Nickoloff & Derek Storch & Wilkins Jackson & Zhi-Jiang Zhang & Yasuaki Hayashino, 2019. "Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-38, March.
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