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Costs of Invasive Meningococcal Disease: A Global Systematic Review

Author

Listed:
  • Bing Wang

    (The University of Adelaide
    The University of Adelaide
    The University of Adelaide
    Women’s and Children’s Hospital)

  • Renee Santoreneos

    (Royal Adelaide Hospital)

  • Hossein Afzali

    (The University of Adelaide)

  • Lynne Giles

    (The University of Adelaide)

  • Helen Marshall

    (The University of Adelaide
    The University of Adelaide
    The University of Adelaide
    Women’s and Children’s Hospital)

Abstract

Background Invasive meningococcal disease remains a public health concern because of its rapid onset and significant risk of death and long-term disability. New meningococcal serogroup B and combination serogroup ACWY vaccines are being considered for publicly funded immunization programs in many countries. Contemporary costing data associated with invasive meningococcal disease are required to inform cost-effectiveness analyses. Objective The objective of this study was to estimate costs and resource utilization associated with acute infection and the long-term care of invasive meningococcal disease. Data Sources and Methods PubMed, EMBASE, The Cochrane Library, health economic databases, and electronically available conference abstracts were searched. Studies reporting any costs associated with acute infection and long-term sequelae of invasive meningococcal disease in English were included. All costs were converted into purchasing power parity-adjusted estimates [international dollars (I$)] using the Campbell and Cochrane Economics Methods Group and the Evidence for Policy and Practice Information and Coordinating Centre cost converter. Results Fourteen studies met our eligibility criteria and were included. The mean costs of acute admission ranged from I$1629 to I$50,796, with an incremental cost of I$16,378. The mean length of hospital stay was reported to be 6–18 days in multiple studies. The average costs reported for readmissions ranged from I$7905 to I$15,908. Key variables such as the presence of sequelae were associated with higher hospitalization costs and longer inpatient stay. No studies estimated direct non-healthcare costs and productivity loss. Ten studies reported only unadjusted mean values without using appropriate statistical methods for adjustment. Conclusions Invasive meningococcal disease can result in substantial costs to healthcare systems. However, costing data on long-term follow-up and indirect costs used to populate health economic models are lacking.

Suggested Citation

  • Bing Wang & Renee Santoreneos & Hossein Afzali & Lynne Giles & Helen Marshall, 2018. "Costs of Invasive Meningococcal Disease: A Global Systematic Review," PharmacoEconomics, Springer, vol. 36(10), pages 1201-1222, October.
    • Handle: RePEc:spr:pharme:v:36:y:2018:i:10:d:10.1007_s40273-018-0679-5
    DOI: 10.1007/s40273-018-0679-5
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    References listed on IDEAS

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    1. Drew Carter & Arlene Vogan & Hossein Haji Ali Afzali, 2016. "Governments Need Better Guidance to Maximise Value for Money: The Case of Australia’s Pharmaceutical Benefits Advisory Committee," Applied Health Economics and Health Policy, Springer, vol. 14(4), pages 401-407, August.
    2. Keith Davis & Timothy Bell & Jacqueline Miller & Derek Misurski & Bela Bapat, 2011. "Hospital costs, length of stay and mortality associated with childhood, adolescent and young Adult meningococcal disease in the US," Applied Health Economics and Health Policy, Springer, vol. 9(3), pages 197-207, May.
    3. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
    4. Borislava Mihaylova & Andrew Briggs & Anthony O'Hagan & Simon G. Thompson, 2011. "Review of statistical methods for analysing healthcare resources and costs," Health Economics, John Wiley & Sons, Ltd., vol. 20(8), pages 897-916, August.
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