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A boosting first-hitting-time model for survival analysis in high-dimensional settings

Author

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  • Riccardo De Bin

    (University of Oslo)

  • Vegard Grødem Stikbakke

    (University of Oslo)

Abstract

In this paper we propose a boosting algorithm to extend the applicability of a first hitting time model to high-dimensional frameworks. Based on an underlying stochastic process, first hitting time models do not require the proportional hazards assumption, hardly verifiable in the high-dimensional context, and represent a valid parametric alternative to the Cox model for modelling time-to-event responses. First hitting time models also offer a natural way to integrate low-dimensional clinical and high-dimensional molecular information in a prediction model, that avoids complicated weighting schemes typical of current methods. The performance of our novel boosting algorithm is illustrated in three real data examples.

Suggested Citation

  • Riccardo De Bin & Vegard Grødem Stikbakke, 2023. "A boosting first-hitting-time model for survival analysis in high-dimensional settings," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(2), pages 420-440, April.
    • Handle: RePEc:spr:lifeda:v:29:y:2023:i:2:d:10.1007_s10985-022-09553-9
    DOI: 10.1007/s10985-022-09553-9
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    References listed on IDEAS

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    1. Hofner, Benjamin & Mayr, Andreas & Schmid, Matthias, 2016. "gamboostLSS: An R Package for Model Building and Variable Selection in the GAMLSS Framework," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 74(i01).
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    6. Riccardo De Bin, 2016. "Boosting in Cox regression: a comparison between the likelihood-based and the model-based approaches with focus on the R-packages CoxBoost and mboost," Computational Statistics, Springer, vol. 31(2), pages 513-531, June.
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    Cited by:

    1. Yiming Chen & Paul J. Smith & Mei-Ling Ting Lee, 2023. "Causal Inference in Threshold Regression and the Neural Network Extension (TRNN)," Stats, MDPI, vol. 6(2), pages 1-24, April.

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