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Application study of the EQ-5D-5L in oncology: linking self-reported quality of life of patients with advanced or metastatic colorectal cancer to clinical data from a German tumor registry

Author

Listed:
  • Kathrin Borchert

    (Xcenda GmbH)

  • Christian Jacob

    (Xcenda GmbH)

  • Natalie Wetzel

    (iOMEDICO AG)

  • Martina Jänicke

    (iOMEDICO AG)

  • Egbert Eggers

    (Kreiskrankenhaus Torgau)

  • Annette Sauer

    (Medizinisches Versorgungszentrum für Blut- und Krebserkrankungen)

  • Norbert Marschner

    (Praxis für interdisziplinäre Onkologie und Hämatologie)

  • Julia Altevers

    (Xcenda GmbH)

  • Thomas Mittendorf

    (Xcenda GmbH)

  • Wolfgang Greiner

    (Universität Bielefeld)

Abstract

Background The EQ-5D-5L questionnaire is used in oncology to generate health-related quality of life (HRQoL) weights and corresponding health states. The purpose was to explore the relationship between demographic and clinical characteristics and HRQoL among advanced or metastatic colorectal cancer (CRC) patients by linking clinical data of a German CRC registry to self-reported HRQoL measures from the EQ-5D-5L. Methods The study sample included patients with advanced or metastatic CRC currently recruited in the German Tumor Registry Colorectal Cancer. The EQ-5D-5L was administered once to patients who were at the start or at later stages of palliative treatment. Data on comorbidities, disease-specific health states, symptoms, and treatment status were drawn from the registry. Multivariate regression analyses were performed to explore the impact of patient and disease characteristics on HRQoL. Results In total, n = 433 questionnaires were included in the data analysis. Mean age of patients was 66.3 years and 61.2% were male. The mean EQ-5D-5L utility score was 0.82 and the mean EQ-5D-5L VAS score was 62.05. The regression analyses revealed that none of the demographic characteristics and few of the clinical characteristics, such as fatigue and pain, had a significant impact on the HRQoL. Conclusions The study demonstrated a reduced HRQoL of patients with advanced or metastatic CRC when compared to the general population. The symptoms fatigue and pain negatively affected the HRQoL, whereas other characteristics such as age, gender, and comorbidities did not have a significant impact on HRQoL.

Suggested Citation

  • Kathrin Borchert & Christian Jacob & Natalie Wetzel & Martina Jänicke & Egbert Eggers & Annette Sauer & Norbert Marschner & Julia Altevers & Thomas Mittendorf & Wolfgang Greiner, 2020. "Application study of the EQ-5D-5L in oncology: linking self-reported quality of life of patients with advanced or metastatic colorectal cancer to clinical data from a German tumor registry," Health Economics Review, Springer, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:spr:hecrev:v:10:y:2020:i:1:d:10.1186_s13561-020-00297-6
    DOI: 10.1186/s13561-020-00297-6
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    References listed on IDEAS

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    1. Daniela Eidt-Koch & Thomas Wagner & Thomas Mittendorf & J.-Matthias Schulenburg, 2010. "Outpatient medication costs of patients with cystic fibrosis in Germany," Applied Health Economics and Health Policy, Springer, vol. 8(2), pages 111-118, March.
    2. Ohrnberger, Julius & Fichera, Eleonora & Sutton, Matt, 2017. "The relationship between physical and mental health: A mediation analysis," Social Science & Medicine, Elsevier, vol. 195(C), pages 42-49.
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    1. Chris Sampson’s journal round-up for 11th January 2021
      by Chris Sampson in The Academic Health Economists' Blog on 2021-01-11 12:00:06

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