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Cost-effectiveness of encorafenib with binimetinib in unresectable or metastatic BRAF-mutant melanoma

Author

Listed:
  • Jean-Baptiste Trouiller

    (Pierre Fabre Laboratories
    Aix-Marseille University)

  • Georgios F. Nikolaidis

    (IQVIA Ltd)

  • Bérengère Macabeo

    (Pierre Fabre Laboratories
    Aix-Marseille University)

  • Nicolas Meyer

    (Cabinet médical, Clinique Médipôle Garonne)

  • Laetitia Gerlier

    (IQVIA Ltd)

  • Max Schlueter

    (IQVIA Ltd)

  • Philippe Laramee

    (Pierre Fabre Laboratories
    Aix-Marseille University)

Abstract

Objective The objective of this study was to determine the cost-effectiveness of encorafenib with binimetinib (EncoBini) as compared to other targeted double combination therapies, namely dabrafenib with trametinib (DabraTrame) and vemurafenib with cobimetinib (VemuCobi), for the treatment of BRAF V600-mutant unresectable or metastatic melanoma (MM) from the French payer perspective. Methods A partitioned survival model was developed considering a lifetime horizon. The model structure simulated the clinical pathway of patients with BRAF V600-mutant MM. Clinical effectiveness and safety inputs were sourced from the COLUMBUS trial, a network meta-analysis and published literature. Costs, resource use, and the quality of life inputs were obtained from the literature and appropriate French sources. Results Over a lifetime horizon, EncoBini was associated, on average, with reduced costs and increased quality adjusted life years (QALYs), dominating both targeted double combination therapies. For a willingness-to-pay threshold of €90,000 per QALY, the probability of EncoBini being cost-effective against either comparator remained above 80%. The most influential model parameters were the hazard ratios for the overall survival of EncoBini vs DabraTrame and VemuCobi, the pre- and post-progression utility values, as well as treatment dosages and the relative dose intensity of all interventions. Conclusion EncoBini is associated with reduced costs and increased QALYs, dominating other targeted double combination therapies (DabraTrame, VemuCobi) for patients with BRAF V600-mutant MM in France. EncoBini is a highly cost-effective intervention in MM.

Suggested Citation

  • Jean-Baptiste Trouiller & Georgios F. Nikolaidis & Bérengère Macabeo & Nicolas Meyer & Laetitia Gerlier & Max Schlueter & Philippe Laramee, 2024. "Cost-effectiveness of encorafenib with binimetinib in unresectable or metastatic BRAF-mutant melanoma," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 25(4), pages 641-653, June.
    • Handle: RePEc:spr:eujhec:v:25:y:2024:i:4:d:10.1007_s10198-023-01614-6
    DOI: 10.1007/s10198-023-01614-6
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    References listed on IDEAS

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