IDEAS home Printed from https://ideas.repec.org/a/spr/eujhec/v22y2021i9d10.1007_s10198-021-01318-9.html
   My bibliography  Save this article

Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly

Author

Listed:
  • Kailu Wang

    (The Chinese University of Hong Kong)

  • Xiaopeng Guo

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Siyue Yu

    (The Chinese University of Hong Kong)

  • Lu Gao

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Zihao Wang

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Huijuan Zhu

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Bing Xing

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Shuyang Zhang

    (China Alliance of Rare Diseases
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Dong Dong

    (The Chinese University of Hong Kong
    Shenzhen Research Institute of Chinese University of Hong Kong)

Abstract

Objective This study aimed to develop a mapping function that links the acromegaly quality of life (AcroQoL) questionnaire to EQ-5D-5L to obtain a preference-based utility value to inform economic evaluation. Methods A nationwide cross-sectional questionnaire survey among patients with acromegaly was conducted online in China during 17 December 2019 to 6 January 2020. The study sample was randomly divided into a training set and a validation set. Ordinary least squares (OLS), Tobit, beta-based mixture, and adjusted limited dependent variable mixture models were tested for development of the function in the training set. Total and subscale scores and individual items of AcroQoL were included as predictors in the models along with their squared terms and demographic and clinical characteristics, and selected by backward stepwise selection. The root mean square error, mean absolute error, Akaike’s information criterion, Bayesian information criterion and adjusted R-square were used to assess goodness of fit and predictive ability of the models. Results There were 424 adult patients with acromegaly eligible for this analysis. Average EQ-5D-5L index score and AcroQoL score for them was 0.82 (SD = 0.15) and 44.3 (SD = 22.9), respectively. A total of 60 candidate models were tested. Considering model simplicity and predictive ability in both training and validation set, the best model was the OLS model using scores of physical dimension and its square term as predictors. Conclusion A validated mapping function was developed in this study for estimating EQ-5D scores using AcroQoL outcomes. Its external validity can be further tested in other population with Acromegaly.

Suggested Citation

  • Kailu Wang & Xiaopeng Guo & Siyue Yu & Lu Gao & Zihao Wang & Huijuan Zhu & Bing Xing & Shuyang Zhang & Dong Dong, 2021. "Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(9), pages 1381-1391, December.
    • Handle: RePEc:spr:eujhec:v:22:y:2021:i:9:d:10.1007_s10198-021-01318-9
    DOI: 10.1007/s10198-021-01318-9
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s10198-021-01318-9
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s10198-021-01318-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Carlos King Ho Wong & Prudence Wing Hang Cheung & Dino Samartzis & Keith Dip-Kei Luk & Kenneth M C Cheung & Cindy Lo Kuen Lam & Jason Pui Yin Cheung, 2017. "Mapping the SRS-22r questionnaire onto the EQ-5D-5L utility score in patients with adolescent idiopathic scoliosis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-12, April.
    2. Michela Meregaglia & Amanda Whittal & Elena Nicod & Michael Drummond, 2020. "‘Mapping’ Health State Utility Values from Non-preference-Based Measures: A Systematic Literature Review in Rare Diseases," PharmacoEconomics, Springer, vol. 38(6), pages 557-574, June.
    3. Mónica Hernández Alava & Allan Wailoo & Fred Wolfe & Kaleb Michaud, 2014. "A Comparison of Direct and Indirect Methods for the Estimation of Health Utilities from Clinical Outcomes," Medical Decision Making, , vol. 34(7), pages 919-930, October.
    4. Ines Buchholz & Mathieu F. Janssen & Thomas Kohlmann & You-Shan Feng, 2018. "A Systematic Review of Studies Comparing the Measurement Properties of the Three-Level and Five-Level Versions of the EQ-5D," PharmacoEconomics, Springer, vol. 36(6), pages 645-661, June.
    5. Linda Ryen & Mikael Svensson, 2015. "The Willingness to Pay for a Quality Adjusted Life Year: A Review of the Empirical Literature," Health Economics, John Wiley & Sons, Ltd., vol. 24(10), pages 1289-1301, October.
    6. Laura A. Gray & Mónica Hernández Alava, 2018. "A command for fitting mixture regression models for bounded dependent variables using the beta distribution," Stata Journal, StataCorp LP, vol. 18(1), pages 51-75, March.
    7. John Brazier & Yaling Yang & Aki Tsuchiya & Donna Rowen, 2010. "A review of studies mapping (or cross walking) non-preference based measures of health to generic preference-based measures," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 11(2), pages 215-225, April.
    8. McDonald, John F & Moffitt, Robert A, 1980. "The Uses of Tobit Analysis," The Review of Economics and Statistics, MIT Press, vol. 62(2), pages 318-321, May.
    9. Alastair M. Gray & Oliver Rivero-Arias & Philip M. Clarke, 2006. "Estimating the Association between SF-12 Responses and EQ-5D Utility Values by Response Mapping," Medical Decision Making, , vol. 26(1), pages 18-29, January.
    10. Monica Hernandez Alava & Allan Wailoo, 2015. "Fitting adjusted limited dependent variable mixture models to EQ-5D," Stata Journal, StataCorp LP, vol. 15(3), pages 737-750, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mona Aghdaee & Bonny Parkinson & Kompal Sinha & Yuanyuan Gu & Rajan Sharma & Emma Olin & Henry Cutler, 2022. "An examination of machine learning to map non‐preference based patient reported outcome measures to health state utility values," Health Economics, John Wiley & Sons, Ltd., vol. 31(8), pages 1525-1557, August.
    2. Richard Huan Xu & Eliza Lai Yi Wong & Jun Jin & Ying Dou & Dong Dong, 2020. "Mapping of the EORTC QLQ-C30 to EQ-5D-5L index in patients with lymphomas," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(9), pages 1363-1373, December.
    3. Fan Yang & Carlos K. H. Wong & Nan Luo & James Piercy & Rebecca Moon & James Jackson, 2019. "Mapping the kidney disease quality of life 36-item short form survey (KDQOL-36) to the EQ-5D-3L and the EQ-5D-5L in patients undergoing dialysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(8), pages 1195-1206, November.
    4. Ning Gu & Chris Bell & Marc Botteman & Xiang Ji & John Carter & Ben Hout, 2012. "Estimating Preference-Based EQ-5D Health State Utilities or Item Responses from Neuropathic Pain Scores," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 5(3), pages 185-197, September.
    5. Asrul Akmal Shafie & Irwinder Kaur Chhabra & Jacqueline Hui Yi Wong & Noor Syahireen Mohammed, 2021. "Mapping PedsQL™ Generic Core Scales to EQ-5D-3L utility scores in transfusion-dependent thalassemia patients," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(5), pages 735-747, July.
    6. Ana Sofia Oliveira Gonçalves & Dimitra Panteli & Lars Neeb & Tobias Kurth & Annette Aigner, 2022. "HIT-6 and EQ-5D-5L in patients with migraine: assessment of common latent constructs and development of a mapping algorithm," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(1), pages 47-57, February.
    7. Hernández-Alava, Mónica & Pudney, Stephen, 2017. "Econometric modelling of multiple self-reports of health states: The switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis," Journal of Health Economics, Elsevier, vol. 55(C), pages 139-152.
    8. Ralph Crott & Andrew Briggs, 2010. "Mapping the QLQ-C30 quality of life cancer questionnaire to EQ-5D patient preferences," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 11(4), pages 427-434, August.
    9. Michael Falk Hvidberg & Mónica Hernández Alava, 2023. "Catalogues of EQ-5D-3L Health-Related Quality of Life Scores for 199 Chronic Conditions and Health Risks for Use in the UK and the USA," PharmacoEconomics, Springer, vol. 41(10), pages 1287-1388, October.
    10. Fan Yang & Nancy Devlin & Nan Luo, 2019. "Impact of mapped EQ-5D utilities on cost-effectiveness analysis: in the case of dialysis treatments," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(1), pages 99-105, February.
    11. Tracey A. Young & Clara Mukuria & Donna Rowen & John E. Brazier & Louise Longworth, 2015. "Mapping Functions in Health-Related Quality of Life," Medical Decision Making, , vol. 35(7), pages 912-926, October.
    12. Billingsley Kaambwa & Lucinda Billingham & Stirling Bryan, 2013. "Mapping utility scores from the Barthel index," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(2), pages 231-241, April.
    13. Bernd Süssmuth, 2012. "The Econometric Analysis of Willingness to Pay for Intangibles with Experience Good Character," Chapters, in: Wolfgang Maennig & Andrew Zimbalist (ed.), International Handbook on the Economics of Mega Sporting Events, chapter 14, Edward Elgar Publishing.
    14. Alston Lee J. & Mueller Bernardo, 2018. "Priests, Conflicts and Property Rights: the Impacts on Tenancy and Land Use in Brazil," Man and the Economy, De Gruyter, vol. 5(1), pages 1-26, June.
    15. Insik Min & Jong‐Ho Kim, 2003. "Modeling Credit Card Borrowing: A Comparison of Type I and Type II Tobit Approaches," Southern Economic Journal, John Wiley & Sons, vol. 70(1), pages 128-143, July.
    16. Fischer, Barbara & Telser, Harry & Zweifel, Peter & von Wyl, Viktor & Beck, Konstantin & Weber, Andreas, 2023. "The value of a QALY towards the end of life and its determinants: Experimental evidence," Social Science & Medicine, Elsevier, vol. 326(C).
    17. Mark Oppe & Daniela Ortín-Sulbarán & Carlos Vila Silván & Anabel Estévez-Carrillo & Juan M. Ramos-Goñi, 2021. "Cost-effectiveness of adding Sativex® spray to spasticity care in Belgium: using bootstrapping instead of Monte Carlo simulation for probabilistic sensitivity analyses," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(5), pages 711-721, July.
    18. Jeff Round & Mike Paulden, 2018. "Incorporating equity in economic evaluations: a multi-attribute equity state approach," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 19(4), pages 489-498, May.
    19. Thomas Bauer & Mathias Sinning, 2011. "The savings behavior of temporary and permanent migrants in Germany," Journal of Population Economics, Springer;European Society for Population Economics, vol. 24(2), pages 421-449, April.
    20. Kumar, Nagesh & Saqib, Mohammed, 1996. "Firm size, opportunities for adaptation and in-house R & D activity in developing countries: the case of Indian manufacturing," Research Policy, Elsevier, vol. 25(5), pages 713-722, August.

    More about this item

    Keywords

    Mapping; Quality of life; EQ-5D; Acromegaly; AcroQoL;
    All these keywords.

    JEL classification:

    • I19 - Health, Education, and Welfare - - Health - - - Other

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:eujhec:v:22:y:2021:i:9:d:10.1007_s10198-021-01318-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.