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A Neighborhood-Wide Association Study (NWAS): Example of prostate cancer aggressiveness

Author

Listed:
  • Shannon M Lynch
  • Nandita Mitra
  • Michelle Ross
  • Craig Newcomb
  • Karl Dailey
  • Tara Jackson
  • Charnita M Zeigler-Johnson
  • Harold Riethman
  • Charles C Branas
  • Timothy R Rebbeck

Abstract

Purpose: Cancer results from complex interactions of multiple variables at the biologic, individual, and social levels. Compared to other levels, social effects that occur geospatially in neighborhoods are not as well-studied, and empiric methods to assess these effects are limited. We propose a novel Neighborhood-Wide Association Study(NWAS), analogous to genome-wide association studies(GWAS), that utilizes high-dimensional computing approaches from biology to comprehensively and empirically identify neighborhood factors associated with disease. Methods: Pennsylvania Cancer Registry data were linked to U.S. Census data. In a successively more stringent multiphase approach, we evaluated the association between neighborhood (n = 14,663 census variables) and prostate cancer aggressiveness(PCA) with n = 6,416 aggressive (Stage≥3/Gleason grade≥7 cases) vs. n = 70,670 non-aggressive (Stage

Suggested Citation

  • Shannon M Lynch & Nandita Mitra & Michelle Ross & Craig Newcomb & Karl Dailey & Tara Jackson & Charnita M Zeigler-Johnson & Harold Riethman & Charles C Branas & Timothy R Rebbeck, 2017. "A Neighborhood-Wide Association Study (NWAS): Example of prostate cancer aggressiveness," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0174548
    DOI: 10.1371/journal.pone.0174548
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    References listed on IDEAS

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    1. Geronimus, A.T. & Hicken, M. & Keene, D. & Bound, J., 2006. ""Weathering" and age patterns of allostatic load scores among blacks and whites in the United States," American Journal of Public Health, American Public Health Association, vol. 96(5), pages 826-833.
    2. Aickin, M. & Gensler, H., 1996. "Adjusting for multiple testing when reporting research results: The Bonferroni vs Holm methods," American Journal of Public Health, American Public Health Association, vol. 86(5), pages 726-728.
    3. Hill, Terrence D. & Angel, Ronald J., 2005. "Neighborhood disorder, psychological distress, and heavy drinking," Social Science & Medicine, Elsevier, vol. 61(5), pages 965-975, September.
    4. Hilary Thomson & Siân Thomas & Eva Sellström & Mark Petticrew, 2013. "Housing Improvements for Health and Associated Socio‐Economic Outcomes: A Systematic Review," Campbell Systematic Reviews, John Wiley & Sons, vol. 9(1), pages 1-348.
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    Cited by:

    1. Shannon M Lynch & Elizabeth Handorf & Kristen A Sorice & Elizabeth Blackman & Lisa Bealin & Veda N Giri & Elias Obeid & Camille Ragin & Mary Daly, 2020. "The effect of neighborhood social environment on prostate cancer development in black and white men at high risk for prostate cancer," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-18, August.
    2. Daniel Wiese & Antoinette M. Stroup & Aniruddha Maiti & Gerald Harris & Shannon M. Lynch & Slobodan Vucetic & Victor H. Gutierrez-Velez & Kevin A. Henry, 2021. "Measuring Neighborhood Landscapes: Associations between a Neighborhood’s Landscape Characteristics and Colon Cancer Survival," IJERPH, MDPI, vol. 18(9), pages 1-19, April.
    3. Angel G. Ortiz & Daniel Wiese & Kristen A. Sorice & Minhhuyen Nguyen & Evelyn T. González & Kevin A. Henry & Shannon M. Lynch, 2020. "Liver Cancer Incidence and Area-Level Geographic Disparities in Pennsylvania—A Geo-Additive Approach," IJERPH, MDPI, vol. 17(20), pages 1-20, October.

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