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Keratin Dynamics: Modeling the Interplay between Turnover and Transport

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  • Stéphanie Portet
  • Anotida Madzvamuse
  • Andy Chung
  • Rudolf E Leube
  • Reinhard Windoffer

Abstract

Keratin are among the most abundant proteins in epithelial cells. Functions of the keratin network in cells are shaped by their dynamical organization. Using a collection of experimentally-driven mathematical models, different hypotheses for the turnover and transport of the keratin material in epithelial cells are tested. The interplay between turnover and transport and their effects on the keratin organization in cells are hence investigated by combining mathematical modeling and experimental data. Amongst the collection of mathematical models considered, a best model strongly supported by experimental data is identified. Fundamental to this approach is the fact that optimal parameter values associated with the best fit for each model are established. The best candidate among the best fits is characterized by the disassembly of the assembled keratin material in the perinuclear region and an active transport of the assembled keratin. Our study shows that an active transport of the assembled keratin is required to explain the experimentally observed keratin organization.

Suggested Citation

  • Stéphanie Portet & Anotida Madzvamuse & Andy Chung & Rudolf E Leube & Reinhard Windoffer, 2015. "Keratin Dynamics: Modeling the Interplay between Turnover and Transport," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-29, March.
    • Handle: RePEc:plo:pone00:0121090
    DOI: 10.1371/journal.pone.0121090
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    1. Dorsey, Robert E & Mayer, Walter J, 1995. "Genetic Algorithms for Estimation Problems with Multiple Optima, Nondifferentiability, and Other Irregular Features," Journal of Business & Economic Statistics, American Statistical Association, vol. 13(1), pages 53-66, January.
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