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Do Mismatches between Pre- and Post-Natal Environments Influence Adult Physiological Functioning?

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  • Tony Robertson
  • Michaela Benzeval

Abstract

Purpose: Mismatches between pre- and post-natal environments have implications for disease in adulthood. However, less is known about how this mismatch can affect physiological systems more generally, especially at younger ages. We hypothesised that mismatches between pre- and post-natal environments, as measured by the measures of birthweight and adult leg length, would be associated with poorer biomarker levels across five key physiological systems in young adults. Methods: Data were collected from 923, 36 year-old respondents from the West of Scotland Twenty-07 Study. The biomarkers were: systolic blood pressure (sBP); forced expiratory volume (FEV1); glycated haemoglobin (HbA1c); glomerular filtration rate (eGFR); and gamma-glutamyltransferase (GGT). These biomarkers were regressed against pre-natal conditions (birthweight), post-natal conditions (leg length) and the interaction between pre- and post-natal measures. Sex, childhood socioeconomic position and adult lifestyle characteristics were adjusted for as potential effect modifiers and confounders, respectively. Results: There were no associations between birthweight and leg length and sBP, FEV1, HbA1c, or GGT. Higher birthweight and longer leg length were associated with better kidney function (eGFR). However, there was no evidence for mismatches between birthweight and leg length to be associated with worse sBP, FEV1, HbA1c, eGFR or GGT levels (P>0.05). Conclusions: Our hypothesis that early signs of physiological damage would be present in young adults given mismatches in childhood environments, as measured by growth markers, was not proven. This lack of association could be because age 36 is too young to identify significant trends for future health, or the associations simply not being present.

Suggested Citation

  • Tony Robertson & Michaela Benzeval, 2014. "Do Mismatches between Pre- and Post-Natal Environments Influence Adult Physiological Functioning?," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0086953
    DOI: 10.1371/journal.pone.0086953
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    1. Patrick Bateson & David Barker & Timothy Clutton-Brock & Debal Deb & Bruno D'Udine & Robert A. Foley & Peter Gluckman & Keith Godfrey & Tom Kirkwood & Marta Mirazón Lahr & John McNamara & Neil B. Metc, 2004. "Developmental plasticity and human health," Nature, Nature, vol. 430(6998), pages 419-421, July.
    2. Langenberg, C. & Shipley, M.J. & Batty, G.D. & Marmot, M.G., 2005. "Adult socioeconomic position and the association between height and coronary heart disease mortality: Findings from 33 years of follow-up in the Whitehall Study," American Journal of Public Health, American Public Health Association, vol. 95(4), pages 628-632.
    3. Lindsay M Silva & Lenie van Rossem & Pauline W Jansen & Anita C S Hokken-Koelega & Henriëtte A Moll & Albert Hofman & Johan P Mackenbach & Vincent W V Jaddoe & Hein Raat, 2012. "Children of Low Socioeconomic Status Show Accelerated Linear Growth in Early Childhood; Results from the Generation R Study," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-10, May.
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