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Influence of Socioeconomic Status Trajectories on Innate Immune Responsiveness in Children

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  • Meghan B Azad
  • Yuri Lissitsyn
  • Gregory E Miller
  • Allan B Becker
  • Kent T HayGlass
  • Anita L Kozyrskyj

Abstract

Objectives: Lower socioeconomic status (SES) is consistently associated with poor health, yet little is known about the biological mechanisms underlying this inequality. In children, we examined the impact of early-life SES trajectories on the intensity of global innate immune activation, recognizing that excessive activation can be a precursor to inflammation and chronic disease. Methods: Stimulated interleukin-6 production, a measure of immune responsiveness, was analyzed ex vivo for 267 Canadian schoolchildren from a 1995 birth cohort in Manitoba, Canada. Childhood SES trajectories were determined from parent-reported housing data using a longitudinal latent-class modeling technique. Multivariate regression was conducted with adjustment for potential confounders. Results: SES was inversely associated with innate immune responsiveness (p = 0.003), with persistently low-SES children exhibiting responses more than twice as intense as their high-SES counterparts. Despite initially lower SES, responses from children experiencing increasing SES trajectories throughout childhood were indistinguishable from high-SES children. Low-SES effects were strongest among overweight children (p

Suggested Citation

  • Meghan B Azad & Yuri Lissitsyn & Gregory E Miller & Allan B Becker & Kent T HayGlass & Anita L Kozyrskyj, 2012. "Influence of Socioeconomic Status Trajectories on Innate Immune Responsiveness in Children," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0038669
    DOI: 10.1371/journal.pone.0038669
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    References listed on IDEAS

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    1. Loucks, Eric B. & Pilote, Louise & Lynch, John W. & Richard, Hugues & Almeida, Nisha D. & Benjamin, Emelia J. & Murabito, Joanne M., 2010. "Life course socioeconomic position is associated with inflammatory markers: The Framingham Offspring Study," Social Science & Medicine, Elsevier, vol. 71(1), pages 187-195, July.
    2. Kozyrskyj, A.L. & Kendall, G.E. & Jacoby, P. & Sly, P.D. & Zubrick, S.R., 2010. "Association between socioeconomic status and the development of asthma: Analyses of income trajectories," American Journal of Public Health, American Public Health Association, vol. 100(3), pages 540-546.
    3. Johnson, R.C. & Schoeni, R.F., 2011. "Early-life origins of adult disease: National longitudinal population-based study of the United States," American Journal of Public Health, American Public Health Association, vol. 101(12), pages 2317-2324.
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    1. Laura Corlin & Mark Woodin & Danny Newhide & Erika Brown & Sarah Valentina Diaz & Amy Chi & Doug Brugge, 2013. "Asthma Associations in Children Attending a Museum of Science," IJERPH, MDPI, vol. 10(9), pages 1-15, September.

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