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The Oxytocin Receptor (OXTR) Contributes to Prosocial Fund Allocations in the Dictator Game and the Social Value Orientations Task

Author

Listed:
  • Salomon Israel
  • Elad Lerer
  • Idan Shalev
  • Florina Uzefovsky
  • Mathias Riebold
  • Efrat Laiba
  • Rachel Bachner-Melman
  • Anat Maril
  • Gary Bornstein
  • Ariel Knafo
  • Richard P Ebstein

Abstract

Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p = 0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2–5 locus haplotypes (p

Suggested Citation

  • Salomon Israel & Elad Lerer & Idan Shalev & Florina Uzefovsky & Mathias Riebold & Efrat Laiba & Rachel Bachner-Melman & Anat Maril & Gary Bornstein & Ariel Knafo & Richard P Ebstein, 2009. "The Oxytocin Receptor (OXTR) Contributes to Prosocial Fund Allocations in the Dictator Game and the Social Value Orientations Task," PLOS ONE, Public Library of Science, vol. 4(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0005535
    DOI: 10.1371/journal.pone.0005535
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    1. Matthijs J H M van der Loos & Cornelius A Rietveld & Niina Eklund & Philipp D Koellinger & Fernando Rivadeneira & Gonçalo R Abecasis & Georgina A Ankra-Badu & Sebastian E Baumeister & Daniel J Benjami, 2013. "The Molecular Genetic Architecture of Self-Employment," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-15, April.
    2. Buser, Thomas & Cappelen, Alexander & Gneezy, Uri & Hoffman, Moshe & Tungodden, Bertil, 2021. "Competitiveness, gender and handedness," Economics & Human Biology, Elsevier, vol. 43(C).
    3. Songfa Zhong & Salomon Israel & Idan Shalev & Hong Xue & Richard P Ebstein & Soo Hong Chew, 2010. "Dopamine D4 Receptor Gene Associated with Fairness Preference in Ultimatum Game," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-8, November.
    4. Thomas Buser, 2010. "Handedness predicts Social Preferences: Evidence connecting the Lab to the Field," Tinbergen Institute Discussion Papers 10-119/3, Tinbergen Institute.
    5. Thomas Buser, 2011. "Hormones and Social Preferences," Tinbergen Institute Discussion Papers 11-046/3, Tinbergen Institute.
    6. Buser, Thomas & Cappelen, Alexander & Gneezy, Uri & Hoffman, Moshe & Tungodden, Bertil, 2020. "Competitiveness, gender and handedness: a large- sample intercultural study," Discussion Paper Series in Economics 2/2020, Norwegian School of Economics, Department of Economics.
    7. Buser, Thomas, 2012. "Digit ratios, the menstrual cycle and social preferences," Games and Economic Behavior, Elsevier, vol. 76(2), pages 457-470.
    8. Vanessa Mertins & Andrea B Schote & Wolfgang Hoffeld & Michele Griessmair & Jobst Meyer, 2011. "Genetic Susceptibility for Individual Cooperation Preferences: The Role of Monoamine Oxidase A Gene (MAOA) in the Voluntary Provision of Public Goods," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-9, June.
    9. Coren L Apicella & David Cesarini & Magnus Johannesson & Christopher T Dawes & Paul Lichtenstein & Björn Wallace & Jonathan Beauchamp & Lars Westberg, 2010. "No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences," PLOS ONE, Public Library of Science, vol. 5(6), pages 1-8, June.
    10. Chew, Soo Hong & Ebstein, Richard P. & Zhong, Songfa, 2013. "Sex-hormone genes and gender difference in ultimatum game: Experimental evidence from China and Israel," Journal of Economic Behavior & Organization, Elsevier, vol. 90(C), pages 28-42.
    11. Cardella, Eric & Kalcheva, Ivalina & Shang, Danjue, 2018. "Financial markets and genetic variation," Journal of International Financial Markets, Institutions and Money, Elsevier, vol. 52(C), pages 64-89.

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