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Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice

Author

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  • Tadaaki Nishioka

    (Osaka University
    Icahn School of Medicine at Mount Sinai)

  • Suthinee Attachaipanich

    (Osaka University)

  • Kosuke Hamaguchi

    (Kyoto University)

  • Michael Lazarus

    (University of Tsukuba)

  • Alban Kerchove d’Exaerde

    (Université Libre de Bruxelles)

  • Tom Macpherson

    (Osaka University)

  • Takatoshi Hikida

    (Osaka University)

Abstract

Learned associations between environmental cues and the outcomes they predict (cue-outcome associations) play a major role in behavioral control, guiding not only which responses we should perform, but also which we should inhibit, in order to achieve a specific goal. The encoding of such cue-outcome associations, as well as the performance of cue-guided choice behavior, is thought to involve dopamine D1 and D2 receptor-expressing medium spiny neurons (D1-/D2-MSNs) of the nucleus accumbens (NAc). Here, using a visual discrimination task in male mice, we assessed the role of NAc D1-/D2-MSNs in cue-guided inhibition of inappropriate responding. Cell-type specific neuronal silencing and in-vivo imaging revealed NAc D2-MSNs to contribute to inhibiting behavioral responses, with activation of NAc D2-MSNs following response errors playing an important role in optimizing future choice behavior. Our findings indicate that error-signaling by NAc D2-MSNs contributes to the ability to use environmental cues to inhibit inappropriate behavior.

Suggested Citation

  • Tadaaki Nishioka & Suthinee Attachaipanich & Kosuke Hamaguchi & Michael Lazarus & Alban Kerchove d’Exaerde & Tom Macpherson & Takatoshi Hikida, 2023. "Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38025-3
    DOI: 10.1038/s41467-023-38025-3
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    1. Ryan Remedios & Ann Kennedy & Moriel Zelikowsky & Benjamin F. Grewe & Mark J. Schnitzer & David J. Anderson, 2017. "Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex," Nature, Nature, vol. 550(7676), pages 388-392, October.
    2. Eduardo F. Gallo & Jozsef Meszaros & Jeremy D. Sherman & Muhammad O. Chohan & Eric Teboul & Claire S. Choi & Holly Moore & Jonathan A. Javitch & Christoph Kellendonk, 2018. "Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    3. Daniel Kahneman & Amos Tversky, 2013. "Prospect Theory: An Analysis of Decision Under Risk," World Scientific Book Chapters, in: Leonard C MacLean & William T Ziemba (ed.), HANDBOOK OF THE FUNDAMENTALS OF FINANCIAL DECISION MAKING Part I, chapter 6, pages 99-127, World Scientific Publishing Co. Pte. Ltd..
    4. Kelly A. Zalocusky & Charu Ramakrishnan & Talia N. Lerner & Thomas J. Davidson & Brian Knutson & Karl Deisseroth, 2016. "Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making," Nature, Nature, vol. 531(7596), pages 642-646, March.
    5. Bin Yang & Tomomi Karigo & David J. Anderson, 2022. "Transformations of neural representations in a social behaviour network," Nature, Nature, vol. 608(7924), pages 741-749, August.
    6. Carina Soares-Cunha & Barbara Coimbra & Ana David-Pereira & Sonia Borges & Luisa Pinto & Patricio Costa & Nuno Sousa & Ana J. Rodrigues, 2016. "Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    7. Nicholas N. Foster & Joshua Barry & Laura Korobkova & Luis Garcia & Lei Gao & Marlene Becerra & Yasmine Sherafat & Bo Peng & Xiangning Li & Jun-Hyeok Choi & Lin Gou & Brian Zingg & Sana Azam & Darrick, 2021. "The mouse cortico–basal ganglia–thalamic network," Nature, Nature, vol. 598(7879), pages 188-194, October.
    8. Qiaojie Xiong & Petr Znamenskiy & Anthony M. Zador, 2015. "Selective corticostriatal plasticity during acquisition of an auditory discrimination task," Nature, Nature, vol. 521(7552), pages 348-351, May.
    9. Yusuke Iino & Takeshi Sawada & Kenji Yamaguchi & Mio Tajiri & Shin Ishii & Haruo Kasai & Sho Yagishita, 2020. "Dopamine D2 receptors in discrimination learning and spine enlargement," Nature, Nature, vol. 579(7800), pages 555-560, March.
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