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Hybrid photoacoustic and fast super-resolution ultrasound imaging

Author

Listed:
  • Shensheng Zhao

    (University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign)

  • Jonathan Hartanto

    (University of Illinois Urbana-Champaign)

  • Ritin Joseph

    (University of Illinois Urbana-Champaign)

  • Cheng-Hsun Wu

    (Verily Life Sciences)

  • Yang Zhao

    (University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign)

  • Yun-Sheng Chen

    (University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign
    University of Illinois Urbana-Champaign)

Abstract

The combination of photoacoustic (PA) imaging and ultrasound localization microscopy (ULM) with microbubbles has great potential in various fields such as oncology, neuroscience, nephrology, and immunology. Here we developed an interleaved PA/fast ULM imaging technique that enables super-resolution vascular and physiological imaging in less than 2 seconds per frame in vivo. By using sparsity-constrained (SC) optimization, we accelerated the frame rate of ULM up to 37 times with synthetic data and 28 times with in vivo data. This allows for the development of a 3D dual imaging sequence with a commonly used linear array imaging system, without the need for complicated motion correction. Using the dual imaging scheme, we demonstrated two in vivo scenarios challenging to image with either technique alone: the visualization of a dye-labeled mouse lymph node showing nearby microvasculature, and a mouse kidney microangiography with tissue oxygenation. This technique offers a powerful tool for mapping tissue physiological conditions and tracking the contrast agent biodistribution non-invasively.

Suggested Citation

  • Shensheng Zhao & Jonathan Hartanto & Ritin Joseph & Cheng-Hsun Wu & Yang Zhao & Yun-Sheng Chen, 2023. "Hybrid photoacoustic and fast super-resolution ultrasound imaging," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37680-w
    DOI: 10.1038/s41467-023-37680-w
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    References listed on IDEAS

    as
    1. Claudia Errico & Juliette Pierre & Sophie Pezet & Yann Desailly & Zsolt Lenkei & Olivier Couture & Mickael Tanter, 2015. "Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging," Nature, Nature, vol. 527(7579), pages 499-502, November.
    2. Yun-Sheng Chen & Soon Joon Yoon & Wolfgang Frey & Mary Dockery & Stanislav Emelianov, 2017. "Dynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
    3. H. W. Kuhn, 1955. "The Hungarian method for the assignment problem," Naval Research Logistics Quarterly, John Wiley & Sons, vol. 2(1‐2), pages 83-97, March.
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