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Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS2 diodes

Author

Listed:
  • Thushani Silva

    (Simon Fraser University)

  • Mirette Fawzy

    (Simon Fraser University)

  • Amirhossein Hasani

    (Simon Fraser University)

  • Hamidreza Ghanbari

    (Simon Fraser University)

  • Amin Abnavi

    (Simon Fraser University)

  • Abdelrahman Askar

    (Simon Fraser University)

  • Yue Ling

    (Simon Fraser University)

  • Mohammad Reza Mohammadzadeh

    (Simon Fraser University)

  • Fahmid Kabir

    (Simon Fraser University)

  • Ribwar Ahmadi

    (Simon Fraser University)

  • Miriam Rosin

    (Simon Fraser University)

  • Karen L. Kavanagh

    (Simon Fraser University)

  • Michael M. Adachi

    (Simon Fraser University)

Abstract

The elevation of cytokine levels in body fluids has been associated with numerous health conditions. The detection of these cytokine biomarkers at low concentrations may help clinicians diagnose diseases at an early stage. Here, we report an asymmetric geometry MoS2 diode-based biosensor for rapid, label-free, highly sensitive, and specific detection of tumor necrosis factor-α (TNF-α), a proinflammatory cytokine. This sensor is functionalized with TNF-α binding aptamers to detect TNF-α at concentrations as low as 10 fM, well below the typical concentrations found in healthy blood. Interactions between aptamers and TNF-α at the sensor surface induce a change in surface energy that alters the current-voltage rectification behavior of the MoS2 diode, which can be read out using a two-electrode configuration. The key advantages of this diode sensor are the simple fabrication process and electrical readout, and therefore, the potential to be applied in a rapid and easy-to-use, point-of-care, diagnostic tool.

Suggested Citation

  • Thushani Silva & Mirette Fawzy & Amirhossein Hasani & Hamidreza Ghanbari & Amin Abnavi & Abdelrahman Askar & Yue Ling & Mohammad Reza Mohammadzadeh & Fahmid Kabir & Ribwar Ahmadi & Miriam Rosin & Kare, 2022. "Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS2 diodes," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35278-2
    DOI: 10.1038/s41467-022-35278-2
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    References listed on IDEAS

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    1. Amritanand Sebastian & Rahul Pendurthi & Tanushree H. Choudhury & Joan M. Redwing & Saptarshi Das, 2021. "Benchmarking monolayer MoS2 and WS2 field-effect transistors," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Antonio Minopoli & Bartolomeo Della Ventura & Bohdan Lenyk & Francesco Gentile & Julian A. Tanner & Andreas Offenhäusser & Dirk Mayer & Raffaele Velotta, 2020. "Ultrasensitive antibody-aptamer plasmonic biosensor for malaria biomarker detection in whole blood," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    3. Michael Taeyoung Hwang & Mohammad Heiranian & Yerim Kim & Seungyong You & Juyoung Leem & Amir Taqieddin & Vahid Faramarzi & Yuhang Jing & Insu Park & Arend M. Zande & Sungwoo Nam & Narayana R. Aluru &, 2020. "Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    4. Jinhua Hong & Zhixin Hu & Matt Probert & Kun Li & Danhui Lv & Xinan Yang & Lin Gu & Nannan Mao & Qingliang Feng & Liming Xie & Jin Zhang & Dianzhong Wu & Zhiyong Zhang & Chuanhong Jin & Wei Ji & Xixia, 2015. "Exploring atomic defects in molybdenum disulphide monolayers," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
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