IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32118-1.html
   My bibliography  Save this article

Decomposing virulence to understand bacterial clearance in persistent infections

Author

Listed:
  • Beatriz Acuña Hidalgo

    (Freie Universität Berlin)

  • Luís M. Silva

    (Freie Universität Berlin
    University of Neuchâtel)

  • Mathias Franz

    (Freie Universität Berlin)

  • Roland R. Regoes

    (Institute of Integrative Biology, ETH Zurich)

  • Sophie A. O. Armitage

    (Freie Universität Berlin)

Abstract

Following an infection, hosts cannot always clear the pathogen, instead either dying or surviving with a persistent infection. Such variation is ecologically and evolutionarily important because it can affect infection prevalence and transmission, and virulence evolution. However, the factors causing variation in infection outcomes, and the relationship between clearance and virulence are not well understood. Here we show that sustained persistent infection and clearance are both possible outcomes across bacterial species showing a range of virulence in Drosophila melanogaster. Variation in virulence arises because of differences in the two components of virulence: bacterial infection intensity inside the host (exploitation), and the amount of damage caused per bacterium (per parasite pathogenicity). As early-phase exploitation increased, clearance rates later in the infection decreased, whereas there was no apparent effect of per parasite pathogenicity on clearance rates. Variation in infection outcomes is thereby determined by how virulence – and its components – relate to the rate of pathogen clearance. Taken together we demonstrate that the virulence decomposition framework is broadly applicable and can provide valuable insights into host-pathogen interactions.

Suggested Citation

  • Beatriz Acuña Hidalgo & Luís M. Silva & Mathias Franz & Roland R. Regoes & Sophie A. O. Armitage, 2022. "Decomposing virulence to understand bacterial clearance in persistent infections," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32118-1
    DOI: 10.1038/s41467-022-32118-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32118-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32118-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rotem Ben-Shachar & Katia Koelle, 2018. "Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    2. A. R. Kraaijeveld & H. C. J. Godfray, 1997. "Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster," Nature, Nature, vol. 389(6648), pages 278-280, September.
    3. Wickham, Hadley, 2011. "The Split-Apply-Combine Strategy for Data Analysis," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 40(i01).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ravic Nijbroek & Kristin Piikki & Mats Söderström & Bas Kempen & Katrine G. Turner & Simeon Hengari & John Mutua, 2018. "Soil Organic Carbon Baselines for Land Degradation Neutrality: Map Accuracy and Cost Tradeoffs with Respect to Complexity in Otjozondjupa, Namibia," Sustainability, MDPI, vol. 10(5), pages 1-20, May.
    2. Miller, Christine M.F. & Waterhouse, Hannah & Harter, Thomas & Fadel, James G. & Meyer, Deanne, 2020. "Quantifying the uncertainty in nitrogen application and groundwater nitrate leaching in manure based cropping systems," Agricultural Systems, Elsevier, vol. 184(C).
    3. Sean McKenzie & Hilary Parkinson & Jane Mangold & Mary Burrows & Selena Ahmed & Fabian Menalled, 2018. "Perceptions, Experiences, and Priorities Supporting Agroecosystem Management Decisions Differ among Agricultural Producers, Consultants, and Researchers," Sustainability, MDPI, vol. 10(11), pages 1-19, November.
    4. Ahmad Alsaber & Jiazhu Pan & Adeeba Al-Herz & Dhary S. Alkandary & Adeeba Al-Hurban & Parul Setiya & on behalf of the KRRD Group, 2020. "Influence of Ambient Air Pollution on Rheumatoid Arthritis Disease Activity Score Index," IJERPH, MDPI, vol. 17(2), pages 1-17, January.
    5. Fulya Gokalp Yavuz & Barret Schloerke, 2020. "Parallel computing in linear mixed models," Computational Statistics, Springer, vol. 35(3), pages 1273-1289, September.
    6. Rebecca Hong & Monica Perkins & Belinda J. Gabbe & Lincoln M. Tracy, 2022. "Comparing Peak Burn Injury Times and Characteristics in Australia and New Zealand," IJERPH, MDPI, vol. 19(15), pages 1-9, August.
    7. Merl, Robert & Stöckl, Thomas & Palan, Stefan, 2023. "Insider trading regulation and shorting constraints. Evaluating the joint effects of two market interventions," Journal of Banking & Finance, Elsevier, vol. 154(C).
    8. Paul J McMurdie & Susan Holmes, 2014. "Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-12, April.
    9. Debanjan Mukherjee & Ângelo Ferreira Chora & Jean-Christophe Lone & Ricardo S. Ramiro & Birte Blankenhaus & Karine Serre & Mário Ramirez & Isabel Gordo & Marc Veldhoen & Patrick Varga-Weisz & Maria M., 2022. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    10. Eff, Ellis Anthon, 2013. "Settlers and surnames: An atlas illustrating the origins of settlers in 19th century America," MPRA Paper 56296, University Library of Munich, Germany.
    11. Nicole Smialek & Joachim Pander & Arne Heinrich & Juergen Geist, 2021. "Sneaker, Dweller and Commuter: Evaluating Fish Behavior in Net-Based Monitoring at Hydropower Plants—A Case Study on Brown Trout ( Salmo trutta )," Sustainability, MDPI, vol. 13(2), pages 1-20, January.
    12. Stefan LINGNER & Eiko THIESSEN & Kerrin MÜLLER & Eberhard HARTUNG, 2018. "Dry Biomass Estimation of Hedge Banks: Allometric Equation vs. Structure from Motion via Unmanned Aerial Vehicle," Journal of Forest Science, Czech Academy of Agricultural Sciences, vol. 64(4), pages 149-156.
    13. Wilson Lara & Stella Bogino & Felipe Bravo, 2018. "Multilevel analysis of dendroclimatic series with the R-package BIOdry," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-23, May.
    14. Alexei Romanioukha & Arseniy S. Karkach & James R. Carey & Anatoli I. Yashin, 2010. "Adaptive trade-off in C. capitata is a characteristic feature of the long-lived subpopulation," MPIDR Working Papers WP-2010-019, Max Planck Institute for Demographic Research, Rostock, Germany.
    15. Mammen, Enno & Wilke, Ralf A. & Zapp, Kristina Maria, 2022. "Estimation of group structures in panel models with individual fixed effects," ZEW Discussion Papers 22-023, ZEW - Leibniz Centre for European Economic Research.
    16. Sara Minoli & Jonas Jägermeyr & Senthold Asseng & Anton Urfels & Christoph Müller, 2022. "Global crop yields can be lifted by timely adaptation of growing periods to climate change," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    17. L. Marie Ende & Katja Knöllinger & Moritz Keil & Angelika J. Fiedler & Marianne Lauerer, 2021. "Possibly Invasive New Bioenergy Crop Silphium perfoliatum : Growth and Reproduction Are Promoted in Moist Soil," Agriculture, MDPI, vol. 11(1), pages 1-13, January.
    18. Carrie M. Leslie & Alva I. Strand & Elizabeth A. Ross & Giovanni Tolentino Ramos & Eli S. Bridge & Phillip B. Chilson & Christopher E. Anderson, 2021. "Shifting the Balance among the ‘Three Rs of Sustainability:’ What Motivates Reducing and Reusing?," Sustainability, MDPI, vol. 13(18), pages 1-12, September.
    19. Cornelius J. König & Clemens B. Fell & Linus Kellnhofer & Gabriel Schui, 2015. "Are there gender differences among researchers from industrial/organizational psychology?," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(3), pages 1931-1952, December.
    20. Kaur, Harsimran & Huggins, David R. & Carlson, Bryan & Stockle, Claudio & Nelson, Roger, 2022. "Dryland fallow vs flex-cropping decisions in inland Pacific Northwest of USA," Agricultural Systems, Elsevier, vol. 201(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32118-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.