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Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews

Author

Listed:
  • Federica Di Spirito

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Alfredo Iandolo

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Alessandra Amato

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Mario Caggiano

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Annunziata Raimondo

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Serena Lembo

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Stefano Martina

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

Abstract

Regardless of rapidly emerging findings on oral lesions described in adult SARS-CoV-2-positive subjects, the evidence level remains quite low and rather contrasting; therefore, the present systematic review of systematic reviews primarily aims to point out the overall prevalence of diagnosed cases. Secondary aims are to estimate the degree of association between oral lesions and SARS-CoV-2 infection and to grade, based on the reported frequency, the primary oral lesions, with related clinical presentations and microscopic features, in relation to COVID-19 forms. A study protocol compliant with the PRISMA statement was developed. Twelve studies were included, reporting highly heterogeneous and incomplete findings, thus precluding a meta-analysis. Further studies should be conducted to assess the overall prevalence of cases diagnosed with oral lesions among adult SARS-CoV-2-positive subjects, especially considering novel viral variants, and to determine their degree of association with SARS-CoV-2 infection and COVID-19 forms. Moreover, the reported findings noticed the need to evaluate the putative role both of SARS-CoV-2 in oral lesions genesis and of periodontitis and periodontal microbiome in COVID-19 worsening and re-activations. Deeper insights into oral lesions in adult SARS-CoV-2-positive subjects could enhance the comprehension of illness pathogenesis, natural history and clinical presentation, thus improving the preparedness of health professionals in the inter-disciplinary management of COVID-19.

Suggested Citation

  • Federica Di Spirito & Alfredo Iandolo & Alessandra Amato & Mario Caggiano & Annunziata Raimondo & Serena Lembo & Stefano Martina, 2022. "Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews," IJERPH, MDPI, vol. 19(12), pages 1-15, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7486-:d:842144
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    References listed on IDEAS

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    1. Giulia Orilisi & Marco Mascitti & Lucrezia Togni & Riccardo Monterubbianesi & Vincenzo Tosco & Flavia Vitiello & Andrea Santarelli & Angelo Putignano & Giovanna Orsini, 2021. "Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review," IJERPH, MDPI, vol. 18(23), pages 1-19, November.
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    1. Mario Caggiano & Alfonso Acerra & Stefano Martina & Marzio Galdi & Francesco D’Ambrosio, 2023. "Infection Control in Dental Practice during the COVID-19 Pandemic: What Is Changed?," IJERPH, MDPI, vol. 20(5), pages 1-10, February.

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