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University alliances and firm exploratory innovation: Evidence from therapeutic product development

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  • Slavova, Kremena
  • Jong, Simcha

Abstract

This paper investigates the relationship between university alliances and firm exploratory innovation in the context of therapeutic product development. We build on organizational learning theory to elucidate that the use of university alliances is more positively associated with firm exploratory rather than exploitative innovation output. Moreover, we argue that the breadth of a firm's technological expertise strengthens the benefits of university alliances in the development of exploratory innovation output. Our empirical analysis is based on a panel dataset of 220 US therapeutic biotechnology firms from 2003 to 2010. Our findings support the contention that university alliances are differentially related to exploratory and exploitative innovation outcomes, and further indicate that firm technological breadth positively moderates the relationship between university alliances and firm exploratory innovation.

Suggested Citation

  • Slavova, Kremena & Jong, Simcha, 2021. "University alliances and firm exploratory innovation: Evidence from therapeutic product development," Technovation, Elsevier, vol. 107(C).
    • Handle: RePEc:eee:techno:v:107:y:2021:i:c:s0166497221000912
    DOI: 10.1016/j.technovation.2021.102310
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    1. Guan, Jiancheng & Liu, Na, 2016. "Exploitative and exploratory innovations in knowledge network and collaboration network: A patent analysis in the technological field of nano-energy," Research Policy, Elsevier, vol. 45(1), pages 97-112.
    2. Jeff S. Armstrong & Michael R. Darby & Lynne G. Zucker, 2003. "Commercializing knowledge: university science, knowledge capture and firm performance in biotechnology," Proceedings, Federal Reserve Bank of Dallas, issue Sep, pages 149-170.
    3. Veugelers, Reinhilde & Cassiman, Bruno, 2005. "R&D cooperation between firms and universities. Some empirical evidence from Belgian manufacturing," International Journal of Industrial Organization, Elsevier, vol. 23(5-6), pages 355-379, June.
    4. Gerard George & Reddi Kotha & Yanfeng Zheng, 2008. "Entry into Insular Domains: A Longitudinal Study of Knowledge Structuration and Innovation in Biotechnology Firms," Journal of Management Studies, Wiley Blackwell, vol. 45(8), pages 1448-1474, December.
    5. Bruneel, Johan & D'Este, Pablo & Salter, Ammon, 2010. "Investigating the factors that diminish the barriers to university-industry collaboration," Research Policy, Elsevier, vol. 39(7), pages 858-868, September.
    6. Justin J. P. Jansen & Frans A. J. Van Den Bosch & Henk W. Volberda, 2006. "Exploratory Innovation, Exploitative Innovation, and Performance: Effects of Organizational Antecedents and Environmental Moderators," Management Science, INFORMS, vol. 52(11), pages 1661-1674, November.
    7. Dushnitsky, Gary & Lenox, Michael J., 2005. "When do incumbents learn from entrepreneurial ventures?: Corporate venture capital and investing firm innovation rates," Research Policy, Elsevier, vol. 34(5), pages 615-639, June.
    8. McMillan, G. Steven & Narin, Francis & Deeds, David L., 2000. "An analysis of the critical role of public science in innovation: the case of biotechnology," Research Policy, Elsevier, vol. 29(1), pages 1-8, January.
    9. Jing Zhang & Charles Baden‐Fuller, 2010. "The Influence of Technological Knowledge Base and Organizational Structure on Technology Collaboration," Journal of Management Studies, Wiley Blackwell, vol. 47(4), pages 679-704, June.
    10. Jing Zhang & Charles Baden-Fuller & Vincent Mangematin, 2007. "Technological Knowledge Base, R&D Organization Structure and Alliance Formation: Evidence from the Biopharmaceutical Industry," Post-Print hal-00424512, HAL.
    11. Gilsing, Victor & Nooteboom, Bart & Vanhaverbeke, Wim & Duysters, Geert & van den Oord, Ad, 2008. "Network embeddedness and the exploration of novel technologies: Technological distance, betweenness centrality and density," Research Policy, Elsevier, vol. 37(10), pages 1717-1731, December.
    12. Julia Porter Liebeskind & Amalya Lumerman Oliver & Lynne Zucker & Marilynn Brewer, 1996. "Social networks, Learning, and Flexibility: Sourcing Scientific Knowledge in New Biotechnology Firms," Organization Science, INFORMS, vol. 7(4), pages 428-443, August.
    13. Hsini Huang & Simcha Jong, 2019. "Public Funding for Science and the Value of Corporate R&D Projects; Evidence from Project Initiation and Termination Decisions in Cell Therapy," Journal of Management Studies, Wiley Blackwell, vol. 56(5), pages 1000-1039, July.
    14. Sam Arts & Lee Fleming, 2018. "Paradise of Novelty—Or Loss of Human Capital? Exploring New Fields and Inventive Output," Organization Science, INFORMS, vol. 29(6), pages 1074-1092, December.
    15. Banerjee, Tannista & Siebert, Ralph, 2017. "Dynamic impact of uncertainty on R&D cooperation formation and research performance: Evidence from the bio-pharmaceutical industry," Research Policy, Elsevier, vol. 46(7), pages 1255-1271.
    16. Hausman, Jerry & Hall, Bronwyn H & Griliches, Zvi, 1984. "Econometric Models for Count Data with an Application to the Patents-R&D Relationship," Econometrica, Econometric Society, vol. 52(4), pages 909-938, July.
    17. Ashish Arora & Sharon Belenzon & Andrea Patacconi, 2018. "The decline of science in corporate R&D," Strategic Management Journal, Wiley Blackwell, vol. 39(1), pages 3-32, January.
    18. Jong, Simcha & Slavova, Kremena, 2014. "When publications lead to products: The open science conundrum in new product development," Research Policy, Elsevier, vol. 43(4), pages 645-654.
    19. Paul E. Bierly & Fariborz Damanpour & Michael D. Santoro, 2009. "The Application of External Knowledge: Organizational Conditions for Exploration and Exploitation," Journal of Management Studies, Wiley Blackwell, vol. 46(3), pages 481-509, May.
    20. Vikas A. Aggarwal & David H. Hsu, 2014. "Entrepreneurial Exits and Innovation," Management Science, INFORMS, vol. 60(4), pages 867-887, April.
    21. Fabrizio, Kira R., 2009. "Absorptive capacity and the search for innovation," Research Policy, Elsevier, vol. 38(2), pages 255-267, March.
    22. Bercovitz, Janet E.L. & Feldman, Maryann P., 2007. "Fishing upstream: Firm innovation strategy and university research alliances," Research Policy, Elsevier, vol. 36(7), pages 930-948, September.
    23. Simeth, Markus & Raffo, Julio D., 2013. "What makes companies pursue an Open Science strategy?," Research Policy, Elsevier, vol. 42(9), pages 1531-1543.
    24. Gautam Ahuja & Curba Morris Lampert, 2001. "Entrepreneurship in the large corporation: a longitudinal study of how established firms create breakthrough inventions," Strategic Management Journal, Wiley Blackwell, vol. 22(6‐7), pages 521-543, June.
    25. Jue Wang & Philip Shapira, 2012. "Partnering with universities: a good choice for nanotechnology start-up firms?," Small Business Economics, Springer, vol. 38(2), pages 197-215, February.
    26. Rebecca R. Kehoe & Daniel Tzabbar, 2015. "Lighting the way or stealing the shine? An examination of the duality in star scientists' effects on firm innovative performance," Strategic Management Journal, Wiley Blackwell, vol. 36(5), pages 709-727, May.
    27. Denisa Mindruta, 2013. "Value creation in university-firm research collaborations: A matching approach," Post-Print hal-00818682, HAL.
    28. Partha, Dasgupta & David, Paul A., 1994. "Toward a new economics of science," Research Policy, Elsevier, vol. 23(5), pages 487-521, September.
    29. Frank T. Rothaermel & David L. Deeds, 2004. "Exploration and exploitation alliances in biotechnology: a system of new product development," Strategic Management Journal, Wiley Blackwell, vol. 25(3), pages 201-221, March.
    30. George, Gerard & Zahra, Shaker A. & Wood, D. Jr., 2002. "The effects of business-university alliances on innovative output and financial performance: a study of publicly traded biotechnology companies," Journal of Business Venturing, Elsevier, vol. 17(6), pages 577-609, October.
    31. Zhang, Jing & Baden-Fuller, Charles & Mangematin, Vincent, 2007. "Technological knowledge base, R&D organization structure and alliance formation: Evidence from the biopharmaceutical industry," Research Policy, Elsevier, vol. 36(4), pages 515-528, May.
    32. Glenn Hoetker, 2007. "The use of logit and probit models in strategic management research: Critical issues," Strategic Management Journal, Wiley Blackwell, vol. 28(4), pages 331-343, April.
    33. Lee Fleming, 2001. "Recombinant Uncertainty in Technological Search," Management Science, INFORMS, vol. 47(1), pages 117-132, January.
    34. James G. March, 1991. "Exploration and Exploitation in Organizational Learning," Organization Science, INFORMS, vol. 2(1), pages 71-87, February.
    35. Du, Jingshu & Leten, Bart & Vanhaverbeke, Wim, 2014. "Managing open innovation projects with science-based and market-based partners," Research Policy, Elsevier, vol. 43(5), pages 828-840.
    36. Michelle Gittelman, 2007. "Does Geography Matter for Science-Based Firms? Epistemic Communities and the Geography of Research and Patenting in Biotechnology," Organization Science, INFORMS, vol. 18(4), pages 724-741, August.
    37. repec:wip:wpaper:6 is not listed on IDEAS
    38. Daniel A. Levinthal & James G. March, 1993. "The myopia of learning," Strategic Management Journal, Wiley Blackwell, vol. 14(S2), pages 95-112, December.
    39. Melissa A. Schilling, 2009. "Understanding the alliance data," Strategic Management Journal, Wiley Blackwell, vol. 30(3), pages 233-260, March.
    40. Simcha Jong, 2006. "How organizational structures in science shape spin-off firms: the biochemistry departments of Berkeley, Stanford, and UCSF and the birth of the biotech industry," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 15(2), pages 251-283, April.
    41. Lori Rosenkopf & Paul Almeida, 2003. "Overcoming Local Search Through Alliances and Mobility," Management Science, INFORMS, vol. 49(6), pages 751-766, June.
    42. Robert M. Grant & Charles Baden‐Fuller, 2004. "A Knowledge Accessing Theory of Strategic Alliances," Journal of Management Studies, Wiley Blackwell, vol. 41(1), pages 61-84, January.
    43. Lori Rosenkopf & Atul Nerkar, 2001. "Beyond local search: boundary‐spanning, exploration, and impact in the optical disk industry," Strategic Management Journal, Wiley Blackwell, vol. 22(4), pages 287-306, April.
    44. Köhler, Christian & Sofka, Wolfgang & Grimpe, Christoph, 2012. "Selective search, sectoral patterns, and the impact on product innovation performance," Research Policy, Elsevier, vol. 41(8), pages 1344-1356.
    45. M. Lourdes Sosa, 2011. "From Old Competence Destruction to New Competence Access: Evidence from the Comparison of Two Discontinuities in Anticancer Drug Discovery," Organization Science, INFORMS, vol. 22(6), pages 1500-1516, December.
    46. Bruno Cassiman & Reinhilde Veugelers & Pluvia Zuniga, 2008. "In search of performance effects of (in)direct industry science links," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 17(4), pages 611-646, August.
    47. Alexander S. Alexiev & Justin J. P. Jansen & Frans A. J. Van den Bosch & Henk W. Volberda, 2010. "Top Management Team Advice Seeking and Exploratory Innovation: The Moderating Role of TMT Heterogeneity," Journal of Management Studies, Wiley Blackwell, vol. 47(7), pages 1343-1364, November.
    48. Walsh, John P. & Lee, You-Na & Nagaoka, Sadao, 2016. "Openness and innovation in the US: Collaboration form, idea generation and implementation," Research Policy, Elsevier, vol. 45(8), pages 1660-1671.
    49. Wirsich, Alexander & Kock, Alexander & Strumann, Christoph & Schultz, Carsten, 2016. "Effects of University Industry Collaboration on Technological Newness," Publications of Darmstadt Technical University, Institute for Business Studies (BWL) 85098, Darmstadt Technical University, Department of Business Administration, Economics and Law, Institute for Business Studies (BWL).
    50. Lee Fleming & Olav Sorenson, 2004. "Science as a map in technological search," Strategic Management Journal, Wiley Blackwell, vol. 25(8‐9), pages 909-928, August.
    51. Soh, Pek-Hooi & Subramanian, Annapoornima M., 2014. "When do firms benefit from university–industry R&D collaborations? The implications of firm R&D focus on scientific research and technological recombination," Journal of Business Venturing, Elsevier, vol. 29(6), pages 807-821.
    52. Cui, Victor & Ding, Waverly W. & Yanadori, Yoshio, 2019. "Exploration versus exploitation in technology firms: The role of compensation structure for R&D workforce," Research Policy, Elsevier, vol. 48(6), pages 1534-1549.
    53. Johan Bruneel & Pablo D’Este & Ammon Salter, 2016. "The impact of financial slack on explorative and exploitative knowledge sourcing from universities: evidence from the UK," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 25(4), pages 689-706.
    54. Denisa Mindruta, 2013. "Value creation in university-firm research collaborations: A matching approach," Strategic Management Journal, Wiley Blackwell, vol. 34(6), pages 644-665, June.
    55. Corey C. Phelps, 2010. "A longitudinal study of the influence of alliance network structure and composition on firm exploratory innovation," Post-Print hal-00528392, HAL.
    56. Stuart, Toby E. & Ozdemir, Salih Zeki & Ding, Waverly W., 2007. "Vertical alliance networks: The case of university-biotechnology-pharmaceutical alliance chains," Research Policy, Elsevier, vol. 36(4), pages 477-498, May.
    57. Ha Hoang & Frank T. Rothaermel, 2010. "Leveraging internal and external experience: exploration, exploitation, and R&D project performance," Strategic Management Journal, Wiley Blackwell, vol. 31(7), pages 734-758, July.
    58. Deeds, David L. & Decarolis, DONA & Coombs, Joseph, 2000. "Dynamic capabilities and new product development in high technology ventures: An empirical analysis of new biotechnology firms," Journal of Business Venturing, Elsevier, vol. 15(3), pages 211-229, May.
    59. Sai Yayavaram & Wei-Ru Chen, 2015. "Changes in firm knowledge couplings and firm innovation performance: The moderating role of technological complexity," Strategic Management Journal, Wiley Blackwell, vol. 36(3), pages 377-396, March.
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