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Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data

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  • Guo, Fangqi
  • Harris, Kathleen Mullan
  • Boardman, Jason D.
  • Robinette, Jennifer W.

Abstract

Living in neighborhoods perceived as disordered exacerbates genetic risk for type 2 diabetes (T2D) among older adults. It is unknown whether this gene-neighborhood interaction extends to younger adults. The present study aims to investigate whether crime, an objectively measured indicator of neighborhood disorder, triggers genetic risk for T2D among younger adults, and whether this hypothesized triggering occurs through exposure to obesity.

Suggested Citation

  • Guo, Fangqi & Harris, Kathleen Mullan & Boardman, Jason D. & Robinette, Jennifer W., 2022. "Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data," Social Science & Medicine, Elsevier, vol. 313(C).
    • Handle: RePEc:eee:socmed:v:313:y:2022:i:c:s027795362200702x
    DOI: 10.1016/j.socscimed.2022.115396
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    References listed on IDEAS

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    1. Teri A. Manolio & Francis S. Collins & Nancy J. Cox & David B. Goldstein & Lucia A. Hindorff & David J. Hunter & Mark I. McCarthy & Erin M. Ramos & Lon R. Cardon & Aravinda Chakravarti & Judy H. Cho &, 2009. "Finding the missing heritability of complex diseases," Nature, Nature, vol. 461(7265), pages 747-753, October.
    2. Stafford, M. & Chandola, T. & Marmot, M., 2007. "Association between fear of crime and mental health and physical functioning," American Journal of Public Health, American Public Health Association, vol. 97(11), pages 2076-2081.
    3. Boardman, J.D. & Daw, J. & Freese, J., 2013. "Defining the environment in gene-environment research: Lessons from social epidemiology," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 64-72.
    4. Robinette, Jennifer W. & Charles, Susan T. & Gruenewald, Tara L., 2018. "Neighborhood cohesion, neighborhood disorder, and cardiometabolic risk," Social Science & Medicine, Elsevier, vol. 198(C), pages 70-76.
    5. Tashi Dendup & Xiaoqi Feng & Stephanie Clingan & Thomas Astell-Burt, 2018. "Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review," IJERPH, MDPI, vol. 15(1), pages 1-25, January.
    6. Chabris, C. F. & Lee, J. J. & Cesarini, D. & Benjamin, D. J. & Laibson, David I., 2015. "The Fourth Law of Behavior Genetics," Scholarly Articles 30780203, Harvard University Department of Economics.
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