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Early origins of socioeconomic inequalities in chronic inflammation: Evaluating the contributions of low birth weight and short breastfeeding

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  • McDade, Thomas W.
  • Koning, Stephanie M.

Abstract

The United States is characterized by persistent and widening social inequities in a wide range of adult health outcomes. A life course approach challenges us to consider if, and how, these inequities trace back to early life conditions, and chronic inflammation represents a potentially important mechanism through which early environments may have lasting effects on health in adulthood. Low birth weight (LBW) and shorter durations of breastfeeding both predict increased inflammation in adulthood, which is associated with increased risk for cardiovascular disease, metabolic syndrome, and all-cause mortality. Using data from a large representative sample of young adults in the US (National Longitudinal Study of Adolescent to Adult Health (Add Health)), we document the socioeconomic status (SES) gradient in chronic inflammation, as indicated by concentrations of C-reactive protein (CRP). Using a nested set of structural equation models and marginal standardization techniques, we investigate the extent to which this gradient is explained by patterns of LBW and breastfeeding in infancy. Findings reveal a particularly important role for breastfeeding duration: Based on model predictive margins, increasing breastfeeding duration to three or more months corresponds to a flattening of the SES gradient by 80%, and 83% when LBW is eliminated. This study expands current understandings of the consequential role of developmental environments for population health and for addressing health inequities in future generations.

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  • McDade, Thomas W. & Koning, Stephanie M., 2021. "Early origins of socioeconomic inequalities in chronic inflammation: Evaluating the contributions of low birth weight and short breastfeeding," Social Science & Medicine, Elsevier, vol. 269(C).
    • Handle: RePEc:eee:socmed:v:269:y:2021:i:c:s027795362030811x
    DOI: 10.1016/j.socscimed.2020.113592
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    References listed on IDEAS

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    1. Thomas W. McDade & Stacy Tessler Lindau & Kristen Wroblewski, 2010. "Predictors of C-Reactive Protein in the National Social Life, Health, and Aging Project," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 66(1), pages 129-136.
    2. Jackson, J.S. & Knight, K.M. & Rafferty, J.A., 2010. "Race and unhealthy behaviors: Chronic stress, the HPA Axis, and physical and mental health disparities over the life course," American Journal of Public Health, American Public Health Association, vol. 100(5), pages 933-939.
    3. Baker, Michael & Milligan, Kevin, 2008. "Maternal employment, breastfeeding, and health: Evidence from maternity leave mandates," Journal of Health Economics, Elsevier, vol. 27(4), pages 871-887, July.
    4. Goosby, Bridget J. & Cheadle, Jacob E. & McDade, Thomas, 2016. "Birth weight, early life course BMI, and body size change: Chains of risk to adult inflammation?," Social Science & Medicine, Elsevier, vol. 148(C), pages 102-109.
    5. Mark Hayward & Bridget Gorman, 2004. "The long arm of childhood: The influence of early-life social conditions on men’s mortality," Demography, Springer;Population Association of America (PAA), vol. 41(1), pages 87-107, February.
    6. Bengtsson, Tommy & Broström, Göran, 2009. "Do conditions in early life affect old-age mortality directly and indirectly? Evidence from 19th-century rural Sweden," Social Science & Medicine, Elsevier, vol. 68(9), pages 1583-1590, May.
    7. Anne Case & Christina Paxson, 2010. "Causes and consequences of early-life health," Demography, Springer;Population Association of America (PAA), vol. 47(1), pages 65-85, March.
    8. Blackwell, Debra L. & Hayward, Mark D. & Crimmins, Eileen M., 2001. "Does childhood health affect chronic morbidity in later life?," Social Science & Medicine, Elsevier, vol. 52(8), pages 1269-1284, April.
    9. repec:pri:cheawb:case_and_paxson_early_life_health_w15637 is not listed on IDEAS
    10. Mackenbach, Johan P. & Kunst, Anton E., 1997. "Measuring the magnitude of socio-economic inequalities in health: An overview of available measures illustrated with two examples from Europe," Social Science & Medicine, Elsevier, vol. 44(6), pages 757-771, March.
    11. repec:pri:cheawb:case_and_paxson_early_life_health_w15637.pdf is not listed on IDEAS
    12. Preston, Samuel H. & Hill, Mark E. & Drevenstedt, Greg L., 1998. "Childhood conditions that predict survival to advanced ages among African-Americans," Social Science & Medicine, Elsevier, vol. 47(9), pages 1231-1246, November.
    13. Cohen, Deborah A. & Farley, Thomas A. & Mason, Karen, 2003. "Why is poverty unhealthy? Social and physical mediators," Social Science & Medicine, Elsevier, vol. 57(9), pages 1631-1641, November.
    14. Woolf, S.H. & Johnson, R.E. & Phillips Jr., R.L. & Philipsen, M., 2007. "Giving everyone the health of the educated: An examination of whether social change would save more lives than medical advances," American Journal of Public Health, American Public Health Association, vol. 97(4), pages 679-683.
    15. repec:pri:rpdevs:case_and_paxson_early_life_health_w15637 is not listed on IDEAS
    16. Marmot, Michael & Ryff, Carol D. & Bumpass, Larry L. & Shipley, Martin & Marks, Nadine F., 1997. "Social inequalities in health: Next questions and converging evidence," Social Science & Medicine, Elsevier, vol. 44(6), pages 901-910, March.
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    1. Chris Sampson’s journal round-up for 25th January 2021
      by Chris Sampson in The Academic Health Economists' Blog on 2021-01-25 12:01:17

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