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Genes, depressive symptoms, and chronic stressors: A nationally representative longitudinal study in the United States

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  • Das, Aniruddha

Abstract

•Polygenic risk for depression predicts late life exposure to chronic stressors.•Women's results suggest weak pleiotropy routed through depression.•These indirect effects are only on baseline stressor variations across individuals.•Men's patterns indicate direct pleiotropy on late life change in stressors.•Holistic life course models incorporating these biological effects are needed.

Suggested Citation

  • Das, Aniruddha, 2019. "Genes, depressive symptoms, and chronic stressors: A nationally representative longitudinal study in the United States," Social Science & Medicine, Elsevier, vol. 242(C).
    • Handle: RePEc:eee:socmed:v:242:y:2019:i:c:s0277953619305817
    DOI: 10.1016/j.socscimed.2019.112586
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    References listed on IDEAS

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    1. Linda Waite & Aniruddha Das, 2010. "Families, social life, and well-being at older ages," Demography, Springer;Population Association of America (PAA), vol. 47(1), pages 87-109, March.
    2. Geronimus, A.T. & Hicken, M. & Keene, D. & Bound, J., 2006. ""Weathering" and age patterns of allostatic load scores among blacks and whites in the United States," American Journal of Public Health, American Public Health Association, vol. 96(5), pages 826-833.
    3. Magnus Johannesson & David I. Laibson & Sarah E. Medland & Michelle N. Meyer & Joseph K. Pickrell & Tõnu Esko & Robert F. Krueger & Jonathan P. Beauchamp & Philipp D. Koellinger & Daniel J. Benjamin &, 2016. "Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses," Post-Print hal-02017373, HAL.
    4. Leonard I. Pearlin, 2010. "The Life Course and the Stress Process: Some Conceptual Comparisons," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 65(2), pages 207-215.
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