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Dirichlet component regression and its applications to psychiatric data

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  • Gueorguieva, Ralitza
  • Rosenheck, Robert
  • Zelterman, Daniel

Abstract

We describe a Dirichlet multivariable regression method useful for modeling data representing components as a percentage of a total. This model is motivated by the unmet need in psychiatry and other areas to simultaneously assess the effects of covariates on the relative contributions of different components of a measure. The model is illustrated using the Positive and Negative Syndrome Scale (PANSS) for assessment of schizophrenia symptoms which, like many other metrics in psychiatry, is composed of a sum of scores on several components, each in turn, made up of sums of evaluations on several questions. We simultaneously examine the effects of baseline socio-demographic and co-morbid correlates on all of the components of the total PANSS score of patients from a schizophrenia clinical trial and identify variables associated with increasing or decreasing relative contributions of each component. Several definitions of residuals are provided. Diagnostics include measures of overdispersion, Cook's distance, and a local jackknife influence metric.

Suggested Citation

  • Gueorguieva, Ralitza & Rosenheck, Robert & Zelterman, Daniel, 2008. "Dirichlet component regression and its applications to psychiatric data," Computational Statistics & Data Analysis, Elsevier, vol. 52(12), pages 5344-5355, August.
    • Handle: RePEc:eee:csdana:v:52:y:2008:i:12:p:5344-5355
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    References listed on IDEAS

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    1. Patricia Espinheira & Silvia Ferrari & Francisco Cribari-Neto, 2008. "On beta regression residuals," Journal of Applied Statistics, Taylor & Francis Journals, vol. 35(4), pages 407-419.
    2. Espinheira, Patri­cia L. & Ferrari, Silvia L.P. & Cribari-Neto, Francisco, 2008. "Influence diagnostics in beta regression," Computational Statistics & Data Analysis, Elsevier, vol. 52(9), pages 4417-4431, May.
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    Cited by:

    1. Monique Graf, 2020. "Regression for compositions based on a generalization of the Dirichlet distribution," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 29(4), pages 913-936, December.
    2. Melo, Tatiane F.N. & Vasconcellos, Klaus L.P. & Lemonte, Artur J., 2009. "Some restriction tests in a new class of regression models for proportions," Computational Statistics & Data Analysis, Elsevier, vol. 53(12), pages 3972-3979, October.
    3. Tsagris, Michail, 2015. "Regression analysis with compositional data containing zero values," MPRA Paper 67868, University Library of Munich, Germany.
    4. Tsagris, Michail, 2015. "A novel, divergence based, regression for compositional data," MPRA Paper 72769, University Library of Munich, Germany.
    5. Angelo Moretti, 2023. "Estimation of small area proportions under a bivariate logistic mixed model," Quality & Quantity: International Journal of Methodology, Springer, vol. 57(4), pages 3663-3684, August.
    6. Graziani, Rebecca & NIGRI, ANDREA, 2023. "An Age–Period–Cohort Model in a Dirichlet Framework: A Coherent Causes of Death Estimation," SocArXiv 856yw, Center for Open Science.
    7. Tsagris, Michail & Preston, Simon & T.A. Wood, Andrew, 2016. "Improved classi cation for compositional data using the $\alpha$-transformation," MPRA Paper 67657, University Library of Munich, Germany.
    8. Michail Tsagris & Simon Preston & Andrew T. A. Wood, 2016. "Improved Classification for Compositional Data Using the α-transformation," Journal of Classification, Springer;The Classification Society, vol. 33(2), pages 243-261, July.
    9. Jamali, Mehdi & Nejat, Ali & Ghosh, Souparno & Jin, Fang & Cao, Guofeng, 2019. "Social media data and post-disaster recovery," International Journal of Information Management, Elsevier, vol. 44(C), pages 25-37.
    10. Jiajia Chen & Xiaoqin Zhang & Shengjia Li, 2017. "Multiple linear regression with compositional response and covariates," Journal of Applied Statistics, Taylor & Francis Journals, vol. 44(12), pages 2270-2285, September.

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