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Predicting Potential Placebo Effect in Drug Treated Subjects

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  • Petkova Eva

    (New York University)

  • Tarpey Thaddeus

    (Wright State University)

  • Govindarajulu Usha

    (Brigham and Women’s Hospital, Harvard University Medical Center)

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    Abstract

    Non-specific responses to treatment (commonly known as placebo response) are pervasive when treating mental illness. Subjects treated with an active drug may respond in part due to non-specific aspects of the treatment, i.e, those not related to the chemical effect of the drug. To determine the extent a subject responds due to the chemical effect of a drug, one must disentangle the specific drug effect from the non-specific placebo effect. This paper presents a unique statistical model that allows for the separate prediction of a specific effect and non-specific effects in drug treated subjects. Data from a clinical trial comparing fluoxetine to a placebo for treating depression is used to illustrate this methodology.

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    File URL: http://www.degruyter.com/view/j/ijb.2009.5.1/ijb.2009.5.1.1152/ijb.2009.5.1.1152.xml?format=INT
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    Bibliographic Info

    Article provided by De Gruyter in its journal The International Journal of Biostatistics.

    Volume (Year): 5 (2009)
    Issue (Month): 1 (July)
    Pages: 1-27

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    Handle: RePEc:bpj:ijbist:v:5:y:2009:i:1:n:23

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    Web page: http://www.degruyter.com

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    Web: http://www.degruyter.com/view/j/ijb

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