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Comparative Efficacy of Combined Formulation of Andrographis paniculata, Lagerstroemia speciosa and Tribulus terrestris with Glimepiride on Renal and Pancreatic Injury in Alloxan Induced Type-1 Diabetic Mice

Author

Listed:
  • Popy Hazra

    (Bangladesh Agricultural University, Bangladesh)

  • Abu Saleh Md Efad Istiak

    (Bangladesh Agricultural University, Bangladesh)

  • Kamrun Nahar Koly

    (Bangladesh Agricultural University, Bangladesh)

  • Fatema Akter

    (Bangladesh Agricultural University, Bangladesh)

  • Md. Faisal Ferdous

    (Bangladesh Agricultural University, Bangladesh)

  • Shila Rani Das

    (Bangladesh Agricultural University, Bangladesh)

  • Mohammad Izmal Hasan

    (Bangladesh Agricultural University, Bangladesh)

  • Azizul Haque

    (Bangladesh Agricultural University, Bangladesh)

  • Sajedul Hayat

    (Bangladesh Agricultural University, Bangladesh)

  • Nasrin Sultana

    (Bangladesh Agricultural University, Bangladesh)

  • Kazi Rafiq

    (Bangladesh Agricultural University, Bangladesh)

Abstract

Many medicinal plants are becoming increasingly popular for the treatment of various ailments, including diabetes, all around the world. This study was designed to elucidate the comparative efficacy of Tribulus terrestris, Andrographis paniculata, and Lagerstroemia speciosa on glucose intolerance, lipid profile, renal and pancreatic injury in alloxan induced type-1 diabetic mice. In this study, four-week-old male Swiss Albino mice were divided into six groups of five each. To assess toxicity, Group-X was given saline water, while Group-Y was given a combination herbal formulation at a high dose (1 g/kg bwt). No adverse effect of combined formula on body weight and blood glucose was observed in normal healthy mice. The other four groups were labeled as Group-A, healthy normal mice; Group-B, Diabetic mice; Group-C, Diabetic mice treated with Andrographis paniculata, Tribulus terristris @ 200 mg/kg and Lagerstroemia speciosa @ 0.5ml/animal; and Group-D, Diabetic mice treated with Amaryl®@ 800 g/kg bwt. The combined formulation improved body weight loss significantly (P

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Handle: RePEc:epw:vetmed:v:3:y:2023:i:3:id:3097
DOI: 10.24018/ejvetmed.2023.3.3.97
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