IDEAS home Printed from https://ideas.repec.org/a/epw/ejchem/v3y2022i3id5115.html

Selective Cytotoxicity of Novel Copper (II) Complex on Colon Cancer Cell Lines

Author

Listed:
  • Zuhal Gerçek

    (Bulent Ecevit University, Turkey.)

  • Ufuk Yıldız

    (Bulent Ecevit University, Turkey.)

  • Remzi Okan Akar

    (Istinye University, Turkey.)

  • Engin Ulukay

    (Istinye University, Turkey.)

Abstract

The synthesis of a novel copper (II) complex, namely, [Cu(phen)(NO2-impi)]2+ (where phen is 1,10-phenanthroline; NO2-impi is 2-(2-(4-nitrophenyl)-5-(pyridin-2-yl)-1H-imidazol-4-yl) pyridine, ZU-3, was performed. UV titration and viscosity measurements were used to determine its interaction with ds-DNA. The binding constant of complex to ds-DNA was 1.3x105 M-1. The Stern-Volmer extinction constant (KSV) for ZU-3 was calculated as 1.2 x 105 M-1. The complex was screened against five human cell lines, namely A 549, PC-3, BEAS-2B, HCT-116 and MDZMB-231, and it was found that ZU-3 shows selective cytotoxicity on colon cancer cells. It has been found that ZU-3 reduced HCT-116 cell density and caused pyknotic morphology that are associated with cell death by apoptosis.

Suggested Citation

Handle: RePEc:epw:ejchem:v:3:y:2022:i:3:id:5115
DOI: 10.24018/ejchem.2022.3.3.115
as

Download full text from publisher

File URL: https://eu-opensci.org/index.php/ejchem/article/view/5115
File Function: Abstract page
Download Restriction: no
File URL: https://eu-opensci.org/index.php/ejchem/article/download/5115/1231
File Function: Full text
Download Restriction: no
File URL: https://libkey.io/10.24018/ejchem.2022.3.3.115?utm_source=ideas
LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
---><---

More about this item

Keywords

;
;
;
;
;

Statistics

Access and download statistics

Corrections

All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:epw:ejchem:v:3:y:2022:i:3:id:5115. See general information about how to correct material in RePEc.

If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

We have no bibliographic references for this item. You can help adding them by using this form .

If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Support Team (email available below). General contact details of provider: https://eu-opensci.org/index.php/ejchem .

Please note that corrections may take a couple of weeks to filter through the various RePEc services.

IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.