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Anti-Hyperglycaemic and Anti-Oxidative Effect of Merremia Tridentata (Linn) Hallier F Ethanol Leaf Extract

Author

Listed:
  • Olubodun A. Adebiyi

    (Ahmadu Bello University, Nigeria)

  • Danladi A. Ameh

    (Ahmadu Bello University, Nigeria)

  • Elewechi Onyike

    (Ahmadu Bello University, Nigeria)

  • Dorcas B. James

    (Ahmadu Bello University, Nigeria)

Abstract

The anti-hyperglycaemic and anti-oxidative effect of Merremia tridentata (Linn) Hallier F ethanol leaf extract (MTELE) was evaluated in this study. Diabetes was induced on male albino wistar rats by a single intra-peritoneal injection of 65mg/kg body weight dose of streptozotocin. The rats were divided into seven groups and treated accordingly with varying doses (50 mg/kg, 75 mg/kg and 100 mg/kg body weight) of MTELE for seven weeks. Body weight and plasma glucose levels were monitored while antioxidant parameters, catalase (CAT), superoxide dismutase (SOD) activities, reduced glutathione (GSH) concentration and levels of thiobarbituric acid reacting substances (TBARS) were determined in the liver and kidney tissues. There was a significant (p

Suggested Citation

Handle: RePEc:epw:ejchem:v:3:y:2022:i:1:id:5087
DOI: 10.24018/ejchem.2022.3.1.87
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