IDEAS home Printed from https://ideas.repec.org/a/epw/ejchem/v1y2020i2id5004.html

Synthesis and Antimicrobial Studies of 6-Aryl and 6-Anilino Benzo[a]phenoxazinones

Author

Listed:
  • Simon Sani Ocholi
  • Efeturi Abraham Onoabedje
  • Samuel Attah Egu

Abstract

Palladium catalyzed Suzuki-Miyaura (SM) and Buchwald – Hartwig (BH) cross-coupling reactions of some phenoxazines are reported. The precursor 9,11-diamino-6-chloro-7-oxa-8,10,12-triaza-benzo [a] anthracen-5-one was prepared by anhydrous base mediated reaction of 2,5,6-triamino-pyrimidin-4-ol and 2,3-dichloro-1,4-naphthoquinone in methanol. The molecular structures of the synthesized compounds agreed with UV/visible, FT-IR, 1H-NMR, MS and elemental analysis data. Using Ciprofloxacin and Ketoconazole as reference drugs, the compounds were screened against six (6) micro-organisms, viz: Listeria ivanovii, Staphylococcus aureus, Klebsiellapneumoniae, Escherichia coli, Candida albicans and Aspergillusnigerand were found to show significant activity against L.ivanovii and E. coli bacteria.

Suggested Citation

  • Simon Sani Ocholi & Efeturi Abraham Onoabedje & Samuel Attah Egu, 2020. "Synthesis and Antimicrobial Studies of 6-Aryl and 6-Anilino Benzo[a]phenoxazinones," European Journal of Advanced Chemistry Research, European Open Science, vol. 1(2), May.
    • Handle: RePEc:epw:ejchem:v:1:y:2020:i:2:id:5004
    DOI: 10.24018/ejchem.2020.1.2.4
    as

    Download full text from publisher

    File URL: https://eu-opensci.org/index.php/ejchem/article/view/5004
    File Function: Abstract page
    Download Restriction: no
    File URL: https://eu-opensci.org/index.php/ejchem/article/download/5004/1181
    File Function: Full text
    Download Restriction: no
    File URL: https://libkey.io/10.24018/ejchem.2020.1.2.4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:epw:ejchem:v:1:y:2020:i:2:id:5004. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Support Team (email available below). General contact details of provider: https://eu-opensci.org/index.php/ejchem .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.