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Synthesis and Antimicrobial Studies of 6-Aryl and 6-Anilino Benzo[a]phenoxazinones

Author

Listed:
  • Simon Sani Ocholi

    (University of Nigeria, Nigeria.)

  • Efeturi Abraham Onoabedje

    (University of Nigeria, Nigeria.)

  • Samuel Attah Egu

    (Kogi State University, Nigeria.)

Abstract

Palladium catalyzed Suzuki-Miyaura (SM) and Buchwald – Hartwig (BH) cross-coupling reactions of some phenoxazines are reported. The precursor 9,11-diamino-6-chloro-7-oxa-8,10,12-triaza-benzo [a] anthracen-5-one was prepared by anhydrous base mediated reaction of 2,5,6-triamino-pyrimidin-4-ol and 2,3-dichloro-1,4-naphthoquinone in methanol. The molecular structures of the synthesized compounds agreed with UV/visible, FT-IR, 1H-NMR, MS and elemental analysis data. Using Ciprofloxacin and Ketoconazole as reference drugs, the compounds were screened against six (6) micro-organisms, viz: Listeria ivanovii, Staphylococcus aureus, Klebsiellapneumoniae, Escherichia coli, Candida albicans and Aspergillusnigerand were found to show significant activity against L.ivanovii and E. coli bacteria.

Suggested Citation

Handle: RePEc:epw:ejchem:v:1:y:2020:i:2:id:5004
DOI: 10.24018/ejchem.2020.1.2.4
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