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Evaluation of Serum Haematological and Electrolyte Changes in Wistar Rats Administered Some Polyherbal Preparations

Author

Listed:
  • Kennedy Iliya Amagon

    (University of Jos, Nigeria)

  • Noel Nen’man Wannang

    (University of Jos, Nigeria)

  • Bukata Bayero Bukar

    (University of Jos, Nigeria)

  • Kakjing Dadul Falang

    (University of Jos, Nigeria)

  • Jacob Adegboyega Kolawole

    (University of Jos, Nigeria)

  • Ukpe Ajima

    (University of Jos, Nigeria)

  • James Garba Damen

    (University of Jos, Nigeria)

  • Yusuf Amuda Agabi

    (University of Jos, Nigeria)

  • Richard Joseph Kutshik

    (University of Jos, Nigeria)

  • Ishaya Yohanna Longdet

    (University of Jos, Nigeria)

  • Simji Samuel Gomerep

    (University of Jos, Nigeria)

  • Ismaila Shittu

    (National Veterinary Research Institute, Nigeria)

  • Stephen Daniel Davou

    (Plateau State Ministry of Health, Nigeria)

Abstract

Coronavirus Disease-19 (COVID-19) has today become a major public health threat. Despite several ongoing clinical trials, there is as yet no specific treatment for this disease. This study evaluated the effects of 3 polyherbal mixtures (CoV-1, CoV Pla-2 and CoV Pla-3) on some electrolyte and haematological parameters in laboratory animals. The parameters evaluated were PCV, HGB, MCV, MCH, MCHC, RBC, WBC, neutrophils and lymphocytes counts, including Na+, Cl-, HCO3-, K+. Treatment was per oral with doses of 100, 200 and 400 mg/kg for the 3 polyherbal mixtures. Control group had 0.1 mL of distilled water per oral. The extract was safe up to 5000 mg/kg. An insignificant (P>0.05) decrease in RBC was observed at all doses except for 200 mg/kg for CoV Pla-3 which was significant (P 0.05) in serum levels of Na+, K+, Cl- and HCO3- were observed in all test animals, compared to control. The results obtained in this study indicate that the extracts did not cause significant changes in haematological parameters evaluated, which implies it is non-toxic.

Suggested Citation

Handle: RePEc:epw:ejbio0:v:1:y:2020:i:5:id:17081
DOI: 10.24018/ejbio.2020.1.5.81
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