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Dr Genetic Association of Angiotensin Converting Enzyme I/D Gene Polymorphisms with Breast Cancer

Author

Listed:
  • Annum Ishfaq

    (University of the Punjab, Pakistan)

  • Ejaz Ali

    (University of the Punjab, Pakistan)

  • Warda Fatima

    (University of the Punjab, Pakistan)

  • Nageen Hussain

    (University of the Punjab, Pakistan)

Abstract

Breast cancer presents a serious public health risk in both developed and developing countries. The ACE gene, which is located in chromosome 17q23, has many polymorphisms. The most commonly studied is a 287 bp Alu insertion/deletion (I/D) polymorphism in intron 16 that accounts for 50% of the variability in circulating ACE levels. The main aim of this study is to find out the association of ACE gene with breast cancer in Pakistani population. Experimental and cross-sectional. A total of 186 samples were collected. Of the 186, 93 were taken as healthy controls and 93 were the female patients suffering from breast cancer. First DNA was isolated and then further genotypes II, ID and DD were identified by Nested PCR. Chi-square (χ2) test was applied to check the association level between ACE I/D polymorphism and breast cancer. The DD genotype showed (76) 81.7% and ID showed (17) 18.2% whereas II was not found (0) 0% in breast cancer patients. In controls, the frequency of DD is (80) 86%, ID (13) 13.9% and (0) 0 percent for II genotype. It is concluded that there is no significant association of ACE I/D polymorphisms with the breast cancer (p

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Handle: RePEc:epw:ejbio0:v:1:y:2020:i:4:id:17041
DOI: 10.24018/ejbio.2020.1.4.41
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