IDEAS home Printed from https://ideas.repec.org/a/epw/biomed/v2y2023i3id2052.html

The Administration of 2% Plum (Prunus domestica L.) Extract Cream Inhibited the Increase of Tyrosinase Enzyme Expression and the Amount of Skin Melanin in Male Guinea Pigs (Cavia porcellus) Skin Exposed to UV B Light

Author

Listed:
  • Mila Damayanti Wahyuningsih

    (University Udayana, Indonesia)

  • Wimpie Pangkahila

    (University Udayana, Indonesia)

  • Ni Wayan Winarti

    (University Udayana, Indonesia)

Abstract

Medical science has progressed a lot and Anti Aging Medicine (AAM) is one of the sciences in the medical world that brings a new paradigm. Hyperpigmentation is one of the most common skin problems caused by excessive pigment melanin production. Plums are nutrient-rich and can be eaten raw, dried, or processed. This research aimed to evaluate the administration of 2% plum extract in inhibiting the increase of tyrosinase enzyme expression and the amount of skin melanin in male guinea pigs’ skin exposed to UV B light. This was a randomized post-test-only control group design using 30 male guinea pigs (Cavia porcellus), aged 12-16 weeks, weight 300-350 grams, and divided into three groups, the control group did not get any cream, treatment group 1 received cream base, and treatment group 2 got 2% plum extract cream. Creams were applied daily 0.1 mg/cm2 at 09.40 and 14.00 WITA. All guinea pigs received UV-B irradiation, three times a week with a total dose of 390 mJ/cm2. Tyrosinase enzyme expression was examined by calculating the percentage of cells expressing the enzyme using immunohistochemical methods. On the other hand, the amount of melanin was obtained by calculating the melanin percentage that appeared on histopathological preparations using Masson-Fontana staining. The data obtained were analyzed using the One-way ANOVA test with a significance value of p

Suggested Citation

Handle: RePEc:epw:biomed:v:2:y:2023:i:3:id:2052
DOI: 10.24018/ejbiomed.2023.2.3.52
as

Download full text from publisher

File URL: https://eu-opensci.org/index.php/ejbiomed/article/view/2052
File Function: Abstract page
Download Restriction: no
File URL: https://eu-opensci.org/index.php/ejbiomed/article/download/2052/489
File Function: Full text
Download Restriction: no
File URL: https://libkey.io/10.24018/ejbiomed.2023.2.3.52?utm_source=ideas
LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
---><---

More about this item

Keywords

;
;
;
;

Statistics

Access and download statistics

Corrections

All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:epw:biomed:v:2:y:2023:i:3:id:2052. See general information about how to correct material in RePEc.

If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

We have no bibliographic references for this item. You can help adding them by using this form .

If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Support Team (email available below). General contact details of provider: https://eu-opensci.org/index.php/ejbiomed .

Please note that corrections may take a couple of weeks to filter through the various RePEc services.

IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.